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Arrhythmogenic Right Ventricular DysplasiaCardiomyopathy Type 1 : A Light on Molecular Mechanisms
Joint Authors
Sieverink, Tom
Vanderschuren, Koen L. A.
Wilders, Ronald
Source
Genetics Research International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited cardiomyopathy associated with cardiac arrhythmias originating in the right ventricle, heart failure, and sudden cardiac death.
Development of ARVD/C type 1 has been attributed to differential expression of transforming growth factor beta 3 (TGFβ3).
Several mechanisms underlying the molecular basis of ARVD/C type 1 have been proposed.
Evaluating previously described mechanisms might elucidate how TGFβ3 contributes to disease progression in ARVD/C type 1.
Here we review how TGFβ3 can induce fibrogenesis through Smad and/or β-catenin signaling.
Moreover, the role of apoptosis is addressed.
Finally the extent to which the immune system has been demonstrated to be a modulating and amplifying agent in the onset and progression of ARVD/C in general is discussed.
American Psychological Association (APA)
Vanderschuren, Koen L. A.& Sieverink, Tom& Wilders, Ronald. 2013. Arrhythmogenic Right Ventricular DysplasiaCardiomyopathy Type 1 : A Light on Molecular Mechanisms. Genetics Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-473334
Modern Language Association (MLA)
Vanderschuren, Koen L. A.…[et al.]. Arrhythmogenic Right Ventricular DysplasiaCardiomyopathy Type 1 : A Light on Molecular Mechanisms. Genetics Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-473334
American Medical Association (AMA)
Vanderschuren, Koen L. A.& Sieverink, Tom& Wilders, Ronald. Arrhythmogenic Right Ventricular DysplasiaCardiomyopathy Type 1 : A Light on Molecular Mechanisms. Genetics Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-473334
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473334