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Ethyl Pyruvate Prevents Methyglyoxal-Induced Retinal Vascular Injury in Rats
Joint Authors
Kim, Chan-Sik
Lee, Yun Mi
Jo, Kyuhyung
Shin, So Dam
Sohn, Eun Jin
Kim, Junghyun
Kim, Jin Sook
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Pyruvate is an endogenous antioxidant substance.
The aim of this study was to investigate the protective effects of ethyl pyruvate (EP) on retinal vascular injury in diabetic retinopathy.
To investigate the protective effect of EP on vascular cell apoptosis and blood-retinal barrier (BRB) breakage, we have used intravitreally methylglyoxal-(MGO-) injected rat eyes.
Apoptosis of the retinal vascular cell that was stimulated by the intravitreal injection of MGO was evidently attenuated by the EP treatment.
EP exerts inhibitory effect on MGO-induced vascular cell apoptosis by blocking oxidative injury.
In addition, EP treatment prevented MGO-induced BRB breakage and the degradation of occludin, an important tight junction protein.
These observations suggest that EP acts through an antioxidant mechanism to protect against oxidative stress-induced apoptosis in retinal vessels.
American Psychological Association (APA)
Kim, Junghyun& Lee, Yun Mi& Kim, Chan-Sik& Sohn, Eun Jin& Jo, Kyuhyung& Shin, So Dam…[et al.]. 2013. Ethyl Pyruvate Prevents Methyglyoxal-Induced Retinal Vascular Injury in Rats. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-473336
Modern Language Association (MLA)
Kim, Junghyun…[et al.]. Ethyl Pyruvate Prevents Methyglyoxal-Induced Retinal Vascular Injury in Rats. Journal of Diabetes Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-473336
American Medical Association (AMA)
Kim, Junghyun& Lee, Yun Mi& Kim, Chan-Sik& Sohn, Eun Jin& Jo, Kyuhyung& Shin, So Dam…[et al.]. Ethyl Pyruvate Prevents Methyglyoxal-Induced Retinal Vascular Injury in Rats. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-473336
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473336