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Commitment of Satellite Cells Expressing the Calcium Channel α2δ1 Subunit to the Muscle Lineage
Joint Authors
Tamayo, Tammy
Grajales, Liliana
García, Jesús
Source
Journal of Signal Transduction
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Satellite cells can maintain or repair muscle because they possess stem cell properties, making them a valuable option for cell therapy.
However, cell transplants into skeletal muscle of patients with muscular dystrophy are limited by donor cell attachment, migration, and survival in the host tissue.
Cells used for therapy are selected based on specific markers present in the plasma membrane.
Although many markers have been identified, there is a need to find a marker that is expressed at different states in satellite cells, activated, quiescent, or differentiated cell.
Furthermore, the marker has to be present in human tissue.
Recently we reported that the plasma membrane α2δ1 protein is involved in cell attachment and migration in myoblasts.
The α2δ1 subunit forms a part of the L-type voltage-dependent calcium channel in adult skeletal muscle.
We found that the α2δ1 subunit is expressed in the majority of newly isolated satellite cells and that it appears earlier than the α1 subunits and at higher levels than the β or γ subunits.
We also found that those cells that expressed α2δ1 would differentiate into muscle cells.
This evidence indicates that the α2δ1 may be used as a marker of satellite cells that will differentiate into muscle.
American Psychological Association (APA)
Tamayo, Tammy& Grajales, Liliana& García, Jesús. 2012. Commitment of Satellite Cells Expressing the Calcium Channel α2δ1 Subunit to the Muscle Lineage. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-473341
Modern Language Association (MLA)
Tamayo, Tammy…[et al.]. Commitment of Satellite Cells Expressing the Calcium Channel α2δ1 Subunit to the Muscle Lineage. Journal of Signal Transduction No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-473341
American Medical Association (AMA)
Tamayo, Tammy& Grajales, Liliana& García, Jesús. Commitment of Satellite Cells Expressing the Calcium Channel α2δ1 Subunit to the Muscle Lineage. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-473341
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473341