Successful Peripheral Blood Stem Cells Collection in Imatinib Pretreated and Nilotinib-Treated Chronic Myeloid Leukemia Patient
Joint Authors
Vozobulova, Vera
Jindra, Pavel
Hrabetova, Marcela
Lysak, Daniel
Vokurka, Samuel
Dvorak, Pavel
Koza, Vladimir
Karas, Michal
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-04
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
We report a case of a successful mobilization and harvest of the peripheral blood stem cells (PBSCs) in imatinib-pretreated and nilotinib treated 52-year-old woman diagnosed with Philadelphia chromosome-positive and BCR-ABL (b2a2) positive chronic phase CML in 2/2002.
She failed interferon-alfa and imatinib treatment.
She achieved her first complete molecular remission after 16 months of nilotinib treatment and later on was mobilized with filgrastim at a dose of 10 ug/kg/day applied subcutaneously once daily.
The total number of 2.98×106 CD34+ cells/kg was harvested on the fourth day of the mobilization.
The autologous graft of the stem cells was cryopreserved and tested for the residual disease: the FISH revealed negative results and the RT-PCR was positive (BCR-ABL/ABL ratio 0,0017 in RQ-PCR).
To our knowledge, this is the first report of successful PBSC harvest in a patient significantly pretreated with imatinib and nilotinib.
American Psychological Association (APA)
Vokurka, Samuel& Koza, Vladimir& Lysak, Daniel& Karas, Michal& Dvorak, Pavel& Jindra, Pavel…[et al.]. 2010. Successful Peripheral Blood Stem Cells Collection in Imatinib Pretreated and Nilotinib-Treated Chronic Myeloid Leukemia Patient. Journal of Oncology،Vol. 2010, no. 2010, pp.1-3.
https://search.emarefa.net/detail/BIM-473346
Modern Language Association (MLA)
Vokurka, Samuel…[et al.]. Successful Peripheral Blood Stem Cells Collection in Imatinib Pretreated and Nilotinib-Treated Chronic Myeloid Leukemia Patient. Journal of Oncology No. 2010 (2010), pp.1-3.
https://search.emarefa.net/detail/BIM-473346
American Medical Association (AMA)
Vokurka, Samuel& Koza, Vladimir& Lysak, Daniel& Karas, Michal& Dvorak, Pavel& Jindra, Pavel…[et al.]. Successful Peripheral Blood Stem Cells Collection in Imatinib Pretreated and Nilotinib-Treated Chronic Myeloid Leukemia Patient. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-3.
https://search.emarefa.net/detail/BIM-473346
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473346
