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Does Long-Term Use of Silver Nanoparticles Have Persistent Inhibitory Effect on H. pylori Based on Mongolian Gerbil’s Model?
Joint Authors
Lu, Chien-Yu
Chen, Yen-Hsu
Kuo, Fu-Chen
Su, Hong-Lin
Chang, Lin-Li
Weng, Bi-Chuang
Liu, Chung-Jung
Kuo, Chao-Hung
Chin, Chieh
Yang, Yuan-Chieh
Wu, Deng-Chyang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
It is urgent to find alternative agents due to increasing failure rate of Helicobacter pylori (H.
pylori) eradication.
The study surveyed the long-term effect of silver nanoparticles (AgNP) on H.
pylori based on Mongolian gerbil’s model.
Materials and Methods.
Fifty gerbils were randomly allocated to six groups (A–F).
Group (Gr) A: the gerbils were fed with broth; Gr B and D: the gerbils were fed with AgNP/clay complex (0.1% of weight); Gr C and E: the gerbils were fed with AgNP/clay complex(1% of weight); and Gr D, E, and F: the gerbils were inoculated with H.
pylori.
At the 20th experimental week, the gerbils were sacrificed.
Histology was evaluated according to the classification of the Sydney system.
P<0.05 was considered to be statistically significant.
Results.
The AgNP/clay has more obvious inhibitory effect on H.
pylori in vitro.
There was a trend of higher concentrations of AgNP with stronger inhibitory effect on H.
pylori growth (P=0.071).
There were no significant differences of inflammation among groups D, E, and F (P=0.688).Conclusion.
AgNP/clay would be a potential and safe agent for inhibiting H.
pylori.
It should be helpful for eradication of H.
pylori infection.
American Psychological Association (APA)
Kuo, Chao-Hung& Lu, Chien-Yu& Yang, Yuan-Chieh& Chin, Chieh& Weng, Bi-Chuang& Liu, Chung-Jung…[et al.]. 2014. Does Long-Term Use of Silver Nanoparticles Have Persistent Inhibitory Effect on H. pylori Based on Mongolian Gerbil’s Model?. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-473359
Modern Language Association (MLA)
Kuo, Chao-Hung…[et al.]. Does Long-Term Use of Silver Nanoparticles Have Persistent Inhibitory Effect on H. pylori Based on Mongolian Gerbil’s Model?. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-473359
American Medical Association (AMA)
Kuo, Chao-Hung& Lu, Chien-Yu& Yang, Yuan-Chieh& Chin, Chieh& Weng, Bi-Chuang& Liu, Chung-Jung…[et al.]. Does Long-Term Use of Silver Nanoparticles Have Persistent Inhibitory Effect on H. pylori Based on Mongolian Gerbil’s Model?. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-473359
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473359