Protein Modification by Dicarbonyl Molecular Species in Neurodegenerative Diseases
Joint Authors
Smith, Mark A.
Weinberg, Aaron
Williams, Wesley M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Neurodegeneration results from abnormalities in cerebral metabolism and energy balance within neurons, astrocytes, microglia, or microvascular endothelial cells of the blood-brain barrier.
In Alzheimer's disease, β-amyloid is considered the primary contributor to neuropathology and neurodegeneration.
It now is believed that certain systemic diseases, such as diabetes mellitus, can contribute to neurodegeneration through the effects of chronic hyperglycemia/insulin resistance resulting in protein glycation, oxidative stress and inflammation within susceptible brain regions.
Here, we present an overview of research focusing on the role of protein glycation, oxidative stress, and inflammation in the neurodegenerative process.
Of special interest in this paper is the effect of methylglyoxal (MGO), a cytotoxic byproduct of glucose metabolism, elevated in neurodegenerative disease, and diabetes mellitus, on cerebral protein function and oxidative stress.
How MGO interacts with amino acid residues within β-amyloid, and small peptides within the brain, is also discussed in terms of the affect on protein function.
American Psychological Association (APA)
Williams, Wesley M.& Weinberg, Aaron& Smith, Mark A.. 2011. Protein Modification by Dicarbonyl Molecular Species in Neurodegenerative Diseases. Journal of Amino Acids،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-473366
Modern Language Association (MLA)
Williams, Wesley M.…[et al.]. Protein Modification by Dicarbonyl Molecular Species in Neurodegenerative Diseases. Journal of Amino Acids No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-473366
American Medical Association (AMA)
Williams, Wesley M.& Weinberg, Aaron& Smith, Mark A.. Protein Modification by Dicarbonyl Molecular Species in Neurodegenerative Diseases. Journal of Amino Acids. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-473366
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473366