Porcine and Canine von Willebrand Factor and von Willebrand Disease : Hemostasis, Thrombosis, and Atherosclerosis Studies
Joint Authors
Kloos, Mark T.
DeFriess, Natalie
Griggs, Thomas R.
Raymer, Robin A.
Ragni, Margaret V.
Nichols, Timothy C.
Merricks, Elizabeth P.
Bellinger, Dwight A.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Use of animal models of inherited and induced von Willebrand factor (VWF) deficiency continues to advance the knowledge of VWF-related diseases: von Willebrand disease (VWD), thrombotic thrombocytopenic purpura (TTP), and coronary artery thrombosis.
First, in humans, pigs, and dogs, VWF is essential for normal hemostasis; without VWF bleeding events are severe and can be fatal.
Second, the ADAMTS13 cleavage site is preserved in all three species suggesting all use this mechanism for normal VWF multimer processing and that all are susceptible to TTP when ADAMTS13 function is reduced.
Third, while the role of VWF in atherogenesis is debated, arterial thrombosis complicating atherosclerosis appears to be VWF-dependent.
The differences in the VWF gene and protein between humans, pigs, and dogs are relatively few but important to consider in the design of VWF-focused experiments.
These homologies and differences are reviewed in detail and their implications for research projects are discussed.
The current status of porcine and canine VWD are also reviewed as well as their potential role in future studies of VWF-related disorders of hemostasis and thrombosis.
American Psychological Association (APA)
Nichols, Timothy C.& Bellinger, Dwight A.& Merricks, Elizabeth P.& Raymer, Robin A.& Kloos, Mark T.& DeFriess, Natalie…[et al.]. 2011. Porcine and Canine von Willebrand Factor and von Willebrand Disease : Hemostasis, Thrombosis, and Atherosclerosis Studies. Thrombosis،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-473368
Modern Language Association (MLA)
Nichols, Timothy C.…[et al.]. Porcine and Canine von Willebrand Factor and von Willebrand Disease : Hemostasis, Thrombosis, and Atherosclerosis Studies. Thrombosis No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-473368
American Medical Association (AMA)
Nichols, Timothy C.& Bellinger, Dwight A.& Merricks, Elizabeth P.& Raymer, Robin A.& Kloos, Mark T.& DeFriess, Natalie…[et al.]. Porcine and Canine von Willebrand Factor and von Willebrand Disease : Hemostasis, Thrombosis, and Atherosclerosis Studies. Thrombosis. 2011. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-473368
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473368