Multiple Sclerosis : A Disorder of Altered T-Cell Homeostasis
Author
Source
Multiple Sclerosis International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Uncertainty exists as to whether similar or different mechanisms contribute to the pathogenesis of different subtypes of multiple sclerosis (MS).
Detailed analysis of naive T cell homeostasis shows that patients with relapsing-remitting MS (RRMS) and with primary progressive MS (PPMS) have early-onset thymic involution that causes reduced thymic output.
The reduced thymic output leads to secondary peripheral homeostatic alterations in naïve CD4 T-cells, which closely mimic T-cell alterations observed in an experimental animal model of diabetes mellitus.
Homeostatic T-cell receptor (TCR) signalling and proliferation of naïve T cells are induced by self-peptides.
Consequently, the findings of increased TCR signalling of naïve CD4 T-cells, without increased proliferation, in PPMS, and the increased homeostatic proliferation of naïve CD4 T-cells in RRMS favour the development of autoimmunity.
Thus, it seems highly likely that peripheral T-cell alterations secondary to a thymic abnormality contribute to the pathogenesis of both MS subtypes.
American Psychological Association (APA)
Haegert, David G.. 2011. Multiple Sclerosis : A Disorder of Altered T-Cell Homeostasis. Multiple Sclerosis International،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-473377
Modern Language Association (MLA)
Haegert, David G.. Multiple Sclerosis : A Disorder of Altered T-Cell Homeostasis. Multiple Sclerosis International No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-473377
American Medical Association (AMA)
Haegert, David G.. Multiple Sclerosis : A Disorder of Altered T-Cell Homeostasis. Multiple Sclerosis International. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-473377
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473377