Therapeutic Strategies for SLE Involving Cytokines : Mechanism-Oriented Therapies Especially IFN-γ Targeting Gene Therapy
Author
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-17
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Systemic lupus erythematosus (SLE: lupus) is a chronic complicated autoimmune disease and pathogenesis is still unclear.
However, key cytokines have been recognized.
Interferon (IFN)-γ and also IFNα/β are of particular importance.
Depending on the concept that lupus is a helper T(Th)1 disease and that dendritic cells (DCs) determine the direction of lupus, balance shift of Th1/Th2 and immunogenic/tolerogenic DCs is reviewed for therapy.
(IFN)-γ- and IFN-α/β-targeted (gene) therapies are introduced.
These consist of Th1/Th2 balance shift and elimination of IFN-γ and IFN-γ-related cytokines such as (interleukin)IL-12 and IL-18.
Other approaches include suppression of immunocompetent cells, normalization of abnormal T-cell function, costimulation blockade, B lymphocyte stimulator (Blys) blockade, and suppression of nephritic kidney inflammation.
Moreover, balance shift of IFN-α/β and tumor necrosis factor (TNF)-α together with regulatory T(Treg) cells are briefely introduced.
Clinical application will be discussed.
American Psychological Association (APA)
Hayashi, Toshiharu. 2010. Therapeutic Strategies for SLE Involving Cytokines : Mechanism-Oriented Therapies Especially IFN-γ Targeting Gene Therapy. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-19.
https://search.emarefa.net/detail/BIM-473414
Modern Language Association (MLA)
Hayashi, Toshiharu. Therapeutic Strategies for SLE Involving Cytokines : Mechanism-Oriented Therapies Especially IFN-γ Targeting Gene Therapy. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-19.
https://search.emarefa.net/detail/BIM-473414
American Medical Association (AMA)
Hayashi, Toshiharu. Therapeutic Strategies for SLE Involving Cytokines : Mechanism-Oriented Therapies Especially IFN-γ Targeting Gene Therapy. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-19.
https://search.emarefa.net/detail/BIM-473414
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473414