Shock Absorbing Function Study on Denucleated Intervertebral Disc with or without Hydrogel Injection through Static and Dynamic Biomechanical Tests In Vitro
Joint Authors
Gao, Manman
Dai, Xuejun
Zhou, Guang-Qian
Liang, Jiabi
Wei, Fuxin
Zou, Xuenong
Zhou, Zhiyu
Deng, Wenbin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Hydrogel injection has been recently proposed as a novel therapy for disc degenerative diseases, with the potential to restore the spine motion and the intervertebral disc height.
However, it remains unknown whether the new technique could also maintain the shock absorbing property of the treated intervertebral disc.
In this study, 18 porcine lumbar bone-disc-bone specimens were collected and randomly divided into three groups: the normal with intact intervertebral discs, the mimic for the injection of disulfide cross-linked hyaluronan hydrogels following discectomy, and the control disc with discectomy only.
In the static compression test, specimens in the mimic group exhibited displacements similar to those in the normal discs, whereas the control group showed a significantly larger displacement range in the first two steps (P<0.05).
With the frequency increasing, all specimens generally displayed an increasing storage modulus, decreasing loss modulus, and tanδ.
At any frequency point, the control group exhibited the largest value in all the three parameters among three groups while the normal group was the lowest, with the mimic group being mostly close to the normal group.
Therefore, the hydrogel injection into the intervertebral discs greatly restored their shock absorbing function, suggesting that the technique could serve as an effective approach to maintaining biomechanical properties of the degenerative intervertebral disc.
American Psychological Association (APA)
Zhou, Zhiyu& Gao, Manman& Wei, Fuxin& Liang, Jiabi& Deng, Wenbin& Dai, Xuejun…[et al.]. 2014. Shock Absorbing Function Study on Denucleated Intervertebral Disc with or without Hydrogel Injection through Static and Dynamic Biomechanical Tests In Vitro. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-473423
Modern Language Association (MLA)
Zhou, Zhiyu…[et al.]. Shock Absorbing Function Study on Denucleated Intervertebral Disc with or without Hydrogel Injection through Static and Dynamic Biomechanical Tests In Vitro. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-473423
American Medical Association (AMA)
Zhou, Zhiyu& Gao, Manman& Wei, Fuxin& Liang, Jiabi& Deng, Wenbin& Dai, Xuejun…[et al.]. Shock Absorbing Function Study on Denucleated Intervertebral Disc with or without Hydrogel Injection through Static and Dynamic Biomechanical Tests In Vitro. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-473423
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473423