Rheumatoid Arthritis Impacts on the Independent Relationships between Circulating Adiponectin Concentrations and Cardiovascular Metabolic Risk
Joint Authors
Norton, Gavin R.
Woodiwiss, Angela J.
Dessein, Patrick H.
Badenhorst, Margaret
Solomon, Ahmed
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Adiponectin and leptin are likely involved in the pathophysiology of rheumatoid arthritis (RA) and therefore potential new therapeutic targets.
Adiponectin inhibition could be expected to enhance cardiovascular metabolic risk.
However, it is unknown whether RA changes the influence of adipokines on cardiovascular metabolic risk.
We determined whether RA impacts on the independent relationships of circulating leptin and adiponectin concentrations with cardiovascular risk factors and carotid intima-media thickness (cIMT) in 277 black African subjects from a developing population; 119 had RA.
RA impacted on the relationships of adiponectin concentrations with lipid concentrations and blood pressure, independent of confounders including adiposity (interaction P<0.05).
This translated into an association of adiponectin concentrations with more favorable lipid variables including HDL cholesterol (P=0.0005), non-HDL cholesterol (P=0.007), and triglyceride (P=0.005) concentrations, total cholesterol-HDL cholesterol (P=0.0002) and triglycerides-HDL cholesterol (P=0.0003) ratios, and higher systolic (P=0.0006), diastolic (P=0.0004), and mean blood pressure (P=0.0007) in RA but not non-RA subjects.
Leptin was not associated with metabolic risk after adjustment for adiposity.
The cIMT did not differ by RA status, and adipokine concentrations were unrelated to atherosclerosis.
This study suggests that leptin and adiponectin inhibition may not alter overall cardiovascular risk and disease in RA.
American Psychological Association (APA)
Dessein, Patrick H.& Norton, Gavin R.& Badenhorst, Margaret& Woodiwiss, Angela J.& Solomon, Ahmed. 2013. Rheumatoid Arthritis Impacts on the Independent Relationships between Circulating Adiponectin Concentrations and Cardiovascular Metabolic Risk. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-473437
Modern Language Association (MLA)
Dessein, Patrick H.…[et al.]. Rheumatoid Arthritis Impacts on the Independent Relationships between Circulating Adiponectin Concentrations and Cardiovascular Metabolic Risk. Mediators of Inflammation No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-473437
American Medical Association (AMA)
Dessein, Patrick H.& Norton, Gavin R.& Badenhorst, Margaret& Woodiwiss, Angela J.& Solomon, Ahmed. Rheumatoid Arthritis Impacts on the Independent Relationships between Circulating Adiponectin Concentrations and Cardiovascular Metabolic Risk. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-473437
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473437