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Hepatitis B Virus Reactivation Induced by Infliximab Administration in a Patient with Crohn’s Disease
Joint Authors
Miyata, Hideki
Nakahara, Hiromasa
Yamago, Hiroka
Imai, Yusuke
Michitaka, Kojiro
Hasebe, Aki
Ninomiya, Keiko
Tanihira, Tetsuya
Tatsukawa, Haruka
Hiraoka, Atsushi
Shiraishi, Akiko
Miyake, Yuka
Shimizu, Yuko
Ninomiya, Tomoyuki
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-09
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
A 47-year-old man diagnosed with Crohn’s disease was treated with infliximab.
He tested negative for hepatitis B surface antigen (HBsAg) and hepatitis B surface antibody (anti-HBs) but positive for anti-HB core antibody (anti-HBc).
He tested positive for hepatitis B virus (HBV-) DNA 3 months after treatment and was administered entecavir.
HBV-DNA test showed negative results 1 month later.
ALT was persistently within the normal range, and HBV-DNA was persistently negative thereafter despite the continuation of infliximab every 8 weeks.
In our hospital, 14 patients with inflammatory bowel disease, who tested negative for HBsAg, were treated with infliximab; 2 of them tested positive for anti-HBs and/or anti-HBc, and HBV reactivation was observed in 1 patient (the present patient).
The present case and these findings highlight that careful follow-up is needed in patients with inflammatory bowel disease treated with infliximab who test positive for anti-HBc and/or anti-HBs.
American Psychological Association (APA)
Miyake, Yuka& Hasebe, Aki& Tanihira, Tetsuya& Shiraishi, Akiko& Imai, Yusuke& Tatsukawa, Haruka…[et al.]. 2013. Hepatitis B Virus Reactivation Induced by Infliximab Administration in a Patient with Crohn’s Disease. Case Reports in Hepatology،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-473442
Modern Language Association (MLA)
Miyake, Yuka…[et al.]. Hepatitis B Virus Reactivation Induced by Infliximab Administration in a Patient with Crohn’s Disease. Case Reports in Hepatology No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-473442
American Medical Association (AMA)
Miyake, Yuka& Hasebe, Aki& Tanihira, Tetsuya& Shiraishi, Akiko& Imai, Yusuke& Tatsukawa, Haruka…[et al.]. Hepatitis B Virus Reactivation Induced by Infliximab Administration in a Patient with Crohn’s Disease. Case Reports in Hepatology. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-473442
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473442