Hyperglycemia, a Neglected Factor during Cancer Progression
Joint Authors
Shen, Xin
Yu, Yongtian
Wu, Erxi
Duan, Wanxing
Lei, Jianjun
Ma, Qingyong
Li, Rong
Xu, Qinhong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Recent evidence from large cohort studies suggests that there exists a higher cancer incidence in people with type 2 diabetes (DM2).
However, to date, the potential reasons for this association remain unclear.
Hyperglycemia, the most important feature of diabetes, may be responsible for the excess glucose supply for these glucose-hungry cells, and it contributes to apoptosis resistance, oncogenesis, and tumor cell resistance to chemotherapy.
Considering associations between diabetes and malignancies, the effect of hyperglycemia on cancer progression in cancer patients with abnormal blood glucose should not be neglected.
In this paper, we describe the role that hyperglycemia plays in cancer progression and treatment and illustrate that hyperglycemia may contribute to a more malignant phenotype of cancer cells and lead to drug resistance.
Therefore, controlling hyperglycemia may have important therapeutic implications in cancer patients.
American Psychological Association (APA)
Duan, Wanxing& Shen, Xin& Lei, Jianjun& Xu, Qinhong& Yu, Yongtian& Li, Rong…[et al.]. 2014. Hyperglycemia, a Neglected Factor during Cancer Progression. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-473447
Modern Language Association (MLA)
Duan, Wanxing…[et al.]. Hyperglycemia, a Neglected Factor during Cancer Progression. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-473447
American Medical Association (AMA)
Duan, Wanxing& Shen, Xin& Lei, Jianjun& Xu, Qinhong& Yu, Yongtian& Li, Rong…[et al.]. Hyperglycemia, a Neglected Factor during Cancer Progression. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-473447
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473447