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Can Diabetes I and Early Blindness Be Prevented Using a Tylenol Combination Which Inhibits Oxidative and Nitrosative Stress?
Joint Authors
Van Thiel, David Hoffman
Van Dyke, Knox
Ghareeb, Erica
Hoeldtke, Robert
Van Dyke, Mark
Van Dyke, Chris
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Since oxidative/nitrosative stress cause diabetes, can we prevent this chemistry generating the disease? Streptozotocin causes diabetes by entering the pancreatic beta cell generating excessive nitric oxide which reacts with oxygen creating a toxin possibly peroxynitrite, dinitrogen trioxide, dinitrogen tetraoxide and so forth.
The toxic compounds damage the DNA causing beta cell death.
This prevents insulin synthesis, storage and release.
By using antioxidant substances that destroy the nitric-oxide-based toxins (e.g., carboxy-PTIO (oxidizes nitric oxide), polyphenolic-quercetin and monophenolic acetaminophen (Tylenol)) which are oxidation and nitration targets can the diabetes I causing toxins in animals be destroyed? Will this tri-drug combination completely prevent the deleterious effects of diabetes namely poor blood glucose control and blindness from cataracts for the entire length of the experiment (one year).
These disease reversal experiments were accomplished in rats where the streptozotocin-diabetic effects were completely thwarted.
In vitro experiments were accomplished to provide the scientific basis for the experimental results in animals.
American Psychological Association (APA)
Van Dyke, Knox& Ghareeb, Erica& Hoeldtke, Robert& Van Dyke, Mark& Van Dyke, Chris& Van Thiel, David Hoffman. 2011. Can Diabetes I and Early Blindness Be Prevented Using a Tylenol Combination Which Inhibits Oxidative and Nitrosative Stress?. ISRN Toxicology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-473448
Modern Language Association (MLA)
Van Dyke, Knox…[et al.]. Can Diabetes I and Early Blindness Be Prevented Using a Tylenol Combination Which Inhibits Oxidative and Nitrosative Stress?. ISRN Toxicology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-473448
American Medical Association (AMA)
Van Dyke, Knox& Ghareeb, Erica& Hoeldtke, Robert& Van Dyke, Mark& Van Dyke, Chris& Van Thiel, David Hoffman. Can Diabetes I and Early Blindness Be Prevented Using a Tylenol Combination Which Inhibits Oxidative and Nitrosative Stress?. ISRN Toxicology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-473448
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473448