Alteration of Energy Substrates and ROS Production in Diabetic Cardiomyopathy
Joint Authors
Tuñón, J.
Lorenzo, O.
Egido, Jesus
Picatoste, B.
Ramírez, E.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Diabetic cardiomyopathy is initiated by alterations in energy substrates.
Despite excess of plasma glucose and lipids, the diabetic heart almost exclusively depends on fatty acid degradation.
Glycolytic enzymes and transporters are impaired by fatty acid metabolism, leading to accumulation of glucose derivatives.
However, fatty acid oxidation yields lower ATP production per mole of oxygen than glucose, causing mitochondrial uncoupling and decreased energy efficiency.
In addition, the oxidation of fatty acids can saturate and cause their deposition in the cytosol, where they deviate to induce toxic metabolites or gene expression by nuclear-receptor interaction.
Hyperglycemia, the fatty acid oxidation pathway, and the cytosolic storage of fatty acid and glucose/fatty acid derivatives are major inducers of reactive oxygen species.
However, the presence of these species can be essential for physiological responses in the diabetic myocardium.
American Psychological Association (APA)
Lorenzo, O.& Ramírez, E.& Picatoste, B.& Egido, Jesus& Tuñón, J.. 2013. Alteration of Energy Substrates and ROS Production in Diabetic Cardiomyopathy. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-473450
Modern Language Association (MLA)
Lorenzo, O.…[et al.]. Alteration of Energy Substrates and ROS Production in Diabetic Cardiomyopathy. Mediators of Inflammation No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-473450
American Medical Association (AMA)
Lorenzo, O.& Ramírez, E.& Picatoste, B.& Egido, Jesus& Tuñón, J.. Alteration of Energy Substrates and ROS Production in Diabetic Cardiomyopathy. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-473450
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473450