The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration

Abstract EN

Netrin-1, a known axon guidance molecule, being a secreted laminin-related molecule, has been suggested to be involved in multiple physiological and pathological conditions, such as organogenesis, angiogenesis, tumorigenesis, and inflammation-mediated tissue injury.

However, its function in thymocyte development is still unknown.

Here, we demonstrate that Netrin-1 is expressed in mouse thymus tissue and is primarily expressed in thymic stromal cells, and the expression of Netrin-1 in thymocytes can be induced by anti-CD3 antibody or IL-7 treatment.

Importantly, Netrin-1 mediates the adhesion of thymocytes, and this effect is comparable to or greater than that of fibronectin.

Furthermore, Netrin-1 specifically promotes the chemotaxis of CXCL12.

These suggest that Netrin-1 may play an important role in thymocyte development.