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NADPH Oxidase as a Therapeutic Target for Oxalate Induced Injury in Kidneys
Joint Authors
Peck, Ammon B.
Khan, Saeed R.
Joshi, Sunil
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-06
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
A major role of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase family of enzymes is to catalyze the production of superoxides and other reactive oxygen species (ROS).
These ROS, in turn, play a key role as messengers in cell signal transduction and cell cycling, but when they are produced in excess they can lead to oxidative stress (OS).
Oxidative stress in the kidneys is now considered a major cause of renal injury and inflammation, giving rise to a variety of pathological disorders.
In this review, we discuss the putative role of oxalate in producing oxidative stress via the production of reactive oxygen species by isoforms of NADPH oxidases expressed in different cellular locations of the kidneys.
Most renal cells produce ROS, and recent data indicate a direct correlation between upregulated gene expressions of NADPH oxidase, ROS, and inflammation.
Renal tissue expression of multiple NADPH oxidase isoforms most likely will impact the future use of different antioxidants and NADPH oxidase inhibitors to minimize OS and renal tissue injury in hyperoxaluria-induced kidney stone disease.
American Psychological Association (APA)
Joshi, Sunil& Peck, Ammon B.& Khan, Saeed R.. 2013. NADPH Oxidase as a Therapeutic Target for Oxalate Induced Injury in Kidneys. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-473468
Modern Language Association (MLA)
Joshi, Sunil…[et al.]. NADPH Oxidase as a Therapeutic Target for Oxalate Induced Injury in Kidneys. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-18.
https://search.emarefa.net/detail/BIM-473468
American Medical Association (AMA)
Joshi, Sunil& Peck, Ammon B.& Khan, Saeed R.. NADPH Oxidase as a Therapeutic Target for Oxalate Induced Injury in Kidneys. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-473468
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473468