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Trends in Early Outpatient Drug Therapy in Pediatric Inflammatory Bowel Disease in Finland : A Nationwide Register-Based Study in 1999–2009
Joint Authors
Virta, Lauri J.
Kolho, Kaija-Leena
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
There are limited data on the changes of treatment strategies of disease-modifying drugs used to treat pediatric inflammatory bowel disease (IBD).
Methods.
We utilized data from two national registers: the Drug Reimbursement Register for drug costs (for identifying children with IBD) and the Drug Purchase Register (for exposure to drugs), both of which are maintained by the Social Insurance Institution of Finland.
The frequencies and trends of drug therapy strategies during the first year of pediatric IBD were evaluated between 1999 and 2009.
Results.
A total of 481 children diagnosed with IBD were identified.
During the first six months, 68% of the patients purchased systemic corticosteroids; these combined with 5-aminosalicylic acid in almost all cases.
The use of corticosteroids was stable from the early years compared with the end of the study period.
In Crohn's disease, there was a trend towards more active use of azathioprine: the therapy was introduced earlier and proportion of pediatric patients purchasing azathioprine increased by up to 51% (P<0.05).
Conclusions.
In pediatric IBD, the majority of patients purchased corticosteroid within the first six months, reflecting moderate-to-severe disease.
During recent years in pediatric Crohn's disease, the therapeutic strategies of oral medication have changed towards more active immunosuppression with azathioprine.
American Psychological Association (APA)
Virta, Lauri J.& Kolho, Kaija-Leena. 2012. Trends in Early Outpatient Drug Therapy in Pediatric Inflammatory Bowel Disease in Finland : A Nationwide Register-Based Study in 1999–2009. ISRN Gastroenterology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-473493
Modern Language Association (MLA)
Virta, Lauri J.& Kolho, Kaija-Leena. Trends in Early Outpatient Drug Therapy in Pediatric Inflammatory Bowel Disease in Finland : A Nationwide Register-Based Study in 1999–2009. ISRN Gastroenterology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-473493
American Medical Association (AMA)
Virta, Lauri J.& Kolho, Kaija-Leena. Trends in Early Outpatient Drug Therapy in Pediatric Inflammatory Bowel Disease in Finland : A Nationwide Register-Based Study in 1999–2009. ISRN Gastroenterology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-473493
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473493