Expression and Clinical Significance of the Autophagy Proteins BECLIN 1 and LC3 in Ovarian Cancer
Joint Authors
Benedetto, Chiara
Morani, Federica
Arisio, Riccardo
Valente, Guido
Isidoro, Ciro
Alabiso, Oscar
Peracchio, Claudia
Fusco, Nicola
Titone, Rossella
Katsaros, Dyonissios
Nicotra, Giuseppina
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Autophagy is dysregulated in cancer and might be involved in ovarian carcinogenesis.
BECLIN-1, a protein that interacts with either BCL-2 or PI3k class III, plays a critical role in the regulation of both autophagy and cell death.
Induction of autophagy is associated with the presence of vacuoles characteristically labelled with the protein LC3.
We have studied the biological and clinical significance of BECLIN 1 and LC3 in ovary tumours of different histological types.
The positive expression of BECLIN 1 was well correlated with the presence of LC3-positive autophagic vacuoles and was inversely correlated with the expression of BCL-2.
The latter inhibits the autophagy function of BECLIN 1.
We found that type I tumours, which are less aggressive than type II, were more frequently expressing high level of BECLIN 1.
Of note, tumours of histologic grade III expressed low level of BECLIN 1.
Consistently, high level of expression of BECLIN 1 and LC3 in tumours is well correlated with the overall survival of the patients.
The present data are compatible with the hypotheses that a low level of autophagy favours cancer progression and that ovary cancer with upregulated autophagy has a less aggressive behaviour and is more responsive to chemotherapy.
American Psychological Association (APA)
Valente, Guido& Morani, Federica& Nicotra, Giuseppina& Fusco, Nicola& Peracchio, Claudia& Titone, Rossella…[et al.]. 2014. Expression and Clinical Significance of the Autophagy Proteins BECLIN 1 and LC3 in Ovarian Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-473494
Modern Language Association (MLA)
Valente, Guido…[et al.]. Expression and Clinical Significance of the Autophagy Proteins BECLIN 1 and LC3 in Ovarian Cancer. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-473494
American Medical Association (AMA)
Valente, Guido& Morani, Federica& Nicotra, Giuseppina& Fusco, Nicola& Peracchio, Claudia& Titone, Rossella…[et al.]. Expression and Clinical Significance of the Autophagy Proteins BECLIN 1 and LC3 in Ovarian Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-473494
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473494