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Clinacanthus nutans Extracts Are Antioxidant with Antiproliferative Effect on Cultured Human Cancer Cell Lines
Joint Authors
Teh, Soek Sin
Tan, Jun Jie
Mah, Siau Hui
Ahmad, Zuraini
Ee, Gwendoline Cheng Lian
Chiong, Hoe Siong
Yong, Yoke Keong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Clinacanthus nutans Lindau leaves (CN) have been used in traditional medicine but the therapeutic potential has not been explored for cancer prevention and treatment.
Current study aimed to evaluate the antioxidant and antiproliferative effects of CN, extracted in chloroform, methanol, and water, on cancer cell lines.
Antioxidant properties of CN were evaluated using DPPH, galvinoxyl, nitric oxide, and hydrogen peroxide based radical scavenging assays, whereas the tumoricidal effect was tested on HepG2, IMR32, NCL-H23, SNU-1, Hela, LS-174T, K562, Raji, and IMR32 cancer cells using MTT assay.
Our data showed that CN in chloroform extract was a good antioxidant against DPPH and galvinoxyl radicals, but less effective in negating nitric oxide and hydrogen peroxide radicals.
Chloroform extract exerted the highest antiproliferative effect on K-562 (91.28±0.03%) and Raji cell lines (88.97±1.07%) at 100 μg/ml and the other five cancer cell lines in a concentration-dependent manner, but not on IMR-32 cells.
Fourteen known compounds were identified in chloroform extract, which was analysed by gas chromatography—mass spectra analysis.
In conclusion, CN extracts possess antioxidant and antiproliferative properties against cultured cancer cell lines, suggesting an alternate adjunctive regimen for cancer prevention or treatment.
American Psychological Association (APA)
Yong, Yoke Keong& Tan, Jun Jie& Teh, Soek Sin& Mah, Siau Hui& Ee, Gwendoline Cheng Lian& Chiong, Hoe Siong…[et al.]. 2013. Clinacanthus nutans Extracts Are Antioxidant with Antiproliferative Effect on Cultured Human Cancer Cell Lines. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-473502
Modern Language Association (MLA)
Yong, Yoke Keong…[et al.]. Clinacanthus nutans Extracts Are Antioxidant with Antiproliferative Effect on Cultured Human Cancer Cell Lines. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-473502
American Medical Association (AMA)
Yong, Yoke Keong& Tan, Jun Jie& Teh, Soek Sin& Mah, Siau Hui& Ee, Gwendoline Cheng Lian& Chiong, Hoe Siong…[et al.]. Clinacanthus nutans Extracts Are Antioxidant with Antiproliferative Effect on Cultured Human Cancer Cell Lines. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-473502
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473502