Structure-Function Relationships behind the Phenomenon of Cognitive Resilience in Neurology : Insights for Neuroscience and Medicine

Author

Rudrauf, David

Source

Advances in Neuroscience

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-28, 28 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-08-03

Country of Publication

Egypt

No. of Pages

28

Main Subjects

Biology
Diseases

Abstract EN

The phenomenon of cognitive resilience, that is, the dynamical preservation of normal functions despite neurological disorders, demonstrates that cognition can be highly robust to devastating brain injury.

Here, cognitive resilience is considered across a range of neurological conditions.

Simple computational models of structure-function relationships are used to discuss hypotheses about the neural mechanisms of resilience.

Resilience expresses functional redundancies in brain networks and suggests a process of dynamic rerouting of brain signals.

This process is underlined by a global renormalization of effective connectivity, capable of restoring information transfer between spared brain structures via alternate pathways.

Local mechanisms of synaptic plasticity mediate the renormalization at the lowest level of implementation, but it is also driven by top-down cognition, with a key role of self-awareness in fostering resilience.

The presence of abstraction layers in brain computation and networking is hypothesized to account for the renormalization process.

Future research directions and challenges are discussed regarding the understanding and control of resilience based on multimodal neuroimaging and computational neuroscience.

The study of resilience will illuminate ways by which the brain can overcome adversity and help inform prevention and treatment strategies.

It is relevant to combating the negative neuropsychological impact of aging and fostering cognitive enhancement.

American Psychological Association (APA)

Rudrauf, David. 2014. Structure-Function Relationships behind the Phenomenon of Cognitive Resilience in Neurology : Insights for Neuroscience and Medicine. Advances in Neuroscience،Vol. 2014, no. 2014, pp.1-28.
https://search.emarefa.net/detail/BIM-473504

Modern Language Association (MLA)

Rudrauf, David. Structure-Function Relationships behind the Phenomenon of Cognitive Resilience in Neurology : Insights for Neuroscience and Medicine. Advances in Neuroscience No. 2014 (2014), pp.1-28.
https://search.emarefa.net/detail/BIM-473504

American Medical Association (AMA)

Rudrauf, David. Structure-Function Relationships behind the Phenomenon of Cognitive Resilience in Neurology : Insights for Neuroscience and Medicine. Advances in Neuroscience. 2014. Vol. 2014, no. 2014, pp.1-28.
https://search.emarefa.net/detail/BIM-473504

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-473504