Duodenal Chromogranin A Cell Density as a Biomarker for the Diagnosis of Irritable Bowel Syndrome
Joint Authors
Gundersen, Doris
Hausken, Trygve
Hatlebakk, Jan Gunnar
Gilja, Odd Helge
El-Salhy, Magdy
Source
Gastroenterology Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background and Aim.
Chromogranin A (CgA) is a common marker for endocrine cells.
The density of duodenal CgA cells is reduced in patients with irritable bowel syndrome (IBS).
Methods.
The present study was undertaken to evaluate the density of duodenal CgA as a biomarker for the diagnosis of IBS.
Two hundred and three patients with IBS were recruited (180 females and 23 males; mean age, 36 years; range, 18–66 years).
The control group comprised 86 healthy subjects without gastrointestinal complaints (77 females and 9 males; mean age, 38 years; range, 18–67 years).
Biopsy samples were taken from the duodenum during gastroscopy.
Sections from these biopsy samples were immunostained for CgA using the avidin-biotin complex (ABC) method.
CgA cell density was quantified by computerized image analysis.
Results.
The CgA cell density was lower in IBS-total and in all of the IBS subgroups than in the controls.
The sensitivity and specificity for a cutoff of <200 cells/mm2 were 86% and 95%, respectively.
Conclusion.
The duodenal CgA cell density seems to be a good biomarker for the diagnosis of IBS.
It is an inexpensive, simple, and easy-to-use method that does not require sophisticated equipment or considerable experience.
American Psychological Association (APA)
El-Salhy, Magdy& Gilja, Odd Helge& Gundersen, Doris& Hatlebakk, Jan Gunnar& Hausken, Trygve. 2014. Duodenal Chromogranin A Cell Density as a Biomarker for the Diagnosis of Irritable Bowel Syndrome. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-473510
Modern Language Association (MLA)
El-Salhy, Magdy…[et al.]. Duodenal Chromogranin A Cell Density as a Biomarker for the Diagnosis of Irritable Bowel Syndrome. Gastroenterology Research and Practice No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-473510
American Medical Association (AMA)
El-Salhy, Magdy& Gilja, Odd Helge& Gundersen, Doris& Hatlebakk, Jan Gunnar& Hausken, Trygve. Duodenal Chromogranin A Cell Density as a Biomarker for the Diagnosis of Irritable Bowel Syndrome. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-473510
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473510