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The Role of the Periaqueductal Gray in the Modulation of Pain in Males and Females : Are the Anatomy and Physiology Really that Different?
Joint Authors
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-01-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Anatomical and physiological studies conducted in the 1960s identified the periaqueductal gray (PAG) and its descending projections to the rostral ventromedial medulla (RVM) and spinal cord dorsal horn, as a primary anatomical pathway mediating opioid-based analgesia.
Since these initial studies, the PAG-RVM-spinal cord pathway has been characterized anatomically and physiologically in a wide range of vertebrate species.
Remarkably, the majority of these studies were conducted exclusively in males with the implicit assumption that the anatomy and physiology of this circuit were the same in females; however, this is not the case.
It is well established that morphine administration produces greater antinociception in males compared to females.
Recent studies indicate that the PAG-RVM pathway contributes to the sexually dimorphic actions of morphine.
This manuscript will review our anatomical, physiological, and behavioral data identifying sex differences in the PAG-RVM pathway, focusing on its role in pain modulation and morphine analgesia.
American Psychological Association (APA)
Loyd, Dayna R.& Murphy, Anne Z.. 2009. The Role of the Periaqueductal Gray in the Modulation of Pain in Males and Females : Are the Anatomy and Physiology Really that Different?. Neural Plasticity،Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-473513
Modern Language Association (MLA)
Loyd, Dayna R.& Murphy, Anne Z.. The Role of the Periaqueductal Gray in the Modulation of Pain in Males and Females : Are the Anatomy and Physiology Really that Different?. Neural Plasticity No. 2009 (2009), pp.1-12.
https://search.emarefa.net/detail/BIM-473513
American Medical Association (AMA)
Loyd, Dayna R.& Murphy, Anne Z.. The Role of the Periaqueductal Gray in the Modulation of Pain in Males and Females : Are the Anatomy and Physiology Really that Different?. Neural Plasticity. 2009. Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-473513
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473513