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Influence of Age, Past Smoking, and Disease Severity on TLR2, Neutrophilic Inflammation, and MMP-9 Levels in COPD
Joint Authors
Simpson, Jodie L.
Wang, Fang
Gibson, Peter G.
Baines, Katherine J.
Oreo, Kevin M.
Hansbro, Philip M.
McDonald, Vanessa M.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-31
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Chronic obstructive pulmonary disease (COPD) is a common and serious respiratory disease, particularly in older individuals, characterised by fixed airway obstruction and persistent airway neutrophilia.
The mechanisms that lead to these features are not well established.
We investigated the contribution of age, prior smoking, and fixed airflow obstruction on sputum neutrophils, TLR2 expression, and markers of neutrophilic inflammation.
Induced sputum from adults with COPD (n=69) and healthy controls (n=51) was examined.
A sputum portion was dispersed, total, differential cell count and viability recorded, and supernatant assayed for CXCL8, matrix metalloproteinase- (MMP-) 9, neutrophil elastase, and soluble TLR2.
Peripheral blood cells (n=7) were stimulated and TLR2 activation examined.
TLR2 levels were increased with ageing, while sputum neutrophils and total sputum MMP-9 levels increased with age, previous smoking, and COPD.
In multivariate regression, TLR2 gene expression and MMP-9 levels were significant independent contributors to the proportion of sputum neutrophils after adjustment for age, prior smoking, and the presence of airflow obstruction.
TLR2 stimulation led to enhanced release of MMP-9 from peripheral blood granulocytes.
TLR2 stimulation activates neutrophils for MMP-9 release.
Efforts to understand the mechanisms of TLR2 signalling and subsequent MMP-9 production in COPD may assist in understanding neutrophilic inflammation in COPD.
American Psychological Association (APA)
Simpson, Jodie L.& McDonald, Vanessa M.& Baines, Katherine J.& Oreo, Kevin M.& Wang, Fang& Hansbro, Philip M.…[et al.]. 2013. Influence of Age, Past Smoking, and Disease Severity on TLR2, Neutrophilic Inflammation, and MMP-9 Levels in COPD. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-473521
Modern Language Association (MLA)
Simpson, Jodie L.…[et al.]. Influence of Age, Past Smoking, and Disease Severity on TLR2, Neutrophilic Inflammation, and MMP-9 Levels in COPD. Mediators of Inflammation No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-473521
American Medical Association (AMA)
Simpson, Jodie L.& McDonald, Vanessa M.& Baines, Katherine J.& Oreo, Kevin M.& Wang, Fang& Hansbro, Philip M.…[et al.]. Influence of Age, Past Smoking, and Disease Severity on TLR2, Neutrophilic Inflammation, and MMP-9 Levels in COPD. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-473521
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473521