Detection of Common Deletional Alpha-Thalassemia Spectrum by Molecular Technique in Kelantan, Northeastern Malaysia
Joint Authors
Marini, R.
Shafini, M. Y.
Nurul Ain, F. A.
Rosline, H.
Rosnah, B.
Abd Allah, Wan Zaidah
Noor Haslina, M. N.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-19
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Thalassemia is a hereditary blood disorder that results from genetic defects causing deficient synthesis of hemoglobin polypeptide chains.
Although thalassemia mostly affects developing countries, there is limited knowledge of its accurate frequency and distribution in these regions.
Knowing the prevalence of thalassemia and the frequency of responsible mutations is therefore an important step in the prevention and control program as well as treatment strategies.
This study was performed to determine the prevalence and to study the spectrum of gene deletions that are responsible in α-thalassemia in Kelantan, located in northeastern Malaysia.
A total 400 first-time blood donors from multiple areas of donation centre were chosen randomly.
The presence of three types of α-thalassemia gene deletion in southeast Asian population which were -SEAdeletion, -α3.7 rightward deletion, and -α4.2 leftward deletion was detected by using multiplex PCR method.
37 (9.25%) of blood donors were confirmed to have α-thalassemia deletion types.
34 (8%) were heterozygous for α3.7 deletion, 1 (0.25%) was heterozygous for α4.2 deletion, and 2 (0.5%) were heterozygous for SEA type deletion.
Alpha-thalassemia-2 with 3.7 deletion was the most common determinant detected in Kelantan Malay compared to other ethnic groups.
It has been noted that alpha-thalassemia-2 with 3.7 deletion is the most common type of α-thalassemia throughout the world.
American Psychological Association (APA)
Rosnah, B.& Rosline, H.& Abd Allah, Wan Zaidah& Noor Haslina, M. N.& Marini, R.& Shafini, M. Y.…[et al.]. 2012. Detection of Common Deletional Alpha-Thalassemia Spectrum by Molecular Technique in Kelantan, Northeastern Malaysia. ISRN Hematology،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-473526
Modern Language Association (MLA)
Rosnah, B.…[et al.]. Detection of Common Deletional Alpha-Thalassemia Spectrum by Molecular Technique in Kelantan, Northeastern Malaysia. ISRN Hematology No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-473526
American Medical Association (AMA)
Rosnah, B.& Rosline, H.& Abd Allah, Wan Zaidah& Noor Haslina, M. N.& Marini, R.& Shafini, M. Y.…[et al.]. Detection of Common Deletional Alpha-Thalassemia Spectrum by Molecular Technique in Kelantan, Northeastern Malaysia. ISRN Hematology. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-473526
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473526