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Leukemia Inhibitory Factor Downregulates Human Papillomavirus-16 Oncogene Expression and Inhibits the Proliferation of Cervical Carcinoma Cells
Joint Authors
Bay, Joseph M.
Teng, Nelson N. H.
Patterson, Bruce K.
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The constitutive proliferation and resistance to differentiation and apoptosis of neoplastic cervical cells depend on sustained expression of human papillomavirus oncogenes.
Inhibition of these oncogenes is a goal for the prevention of progression of HPV-induced neoplasias to cervical cancer.
SiHa cervical cancer cells were transfected with an HPV-16 promoter reporter construct and treated with leukemia inhibitory factor (LIF), a human cytokine of the interleukin 6 superfamily.
SiHa and CaSki cervical cancer cells were also assessed for proliferation by MTT precipitation, programmed cell death by flow cytometry, and HPV E6 and E7 expression by real-time PCR.
LIF-treated cervical cancer cells showed significantly reduced HPV LCR activation, reduced levels of E6 and E7 mRNA, and reduced proliferation.
We report the novel use of LIF to inhibit viral oncogene expression in cervical cancer cells, with concomitant reduction in proliferation suggesting re-engagement of cell-cycle regulation.
American Psychological Association (APA)
Bay, Joseph M.& Patterson, Bruce K.& Teng, Nelson N. H.. 2011. Leukemia Inhibitory Factor Downregulates Human Papillomavirus-16 Oncogene Expression and Inhibits the Proliferation of Cervical Carcinoma Cells. Infectious Diseases in Obstetrics and Gynecology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-473536
Modern Language Association (MLA)
Bay, Joseph M.…[et al.]. Leukemia Inhibitory Factor Downregulates Human Papillomavirus-16 Oncogene Expression and Inhibits the Proliferation of Cervical Carcinoma Cells. Infectious Diseases in Obstetrics and Gynecology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-473536
American Medical Association (AMA)
Bay, Joseph M.& Patterson, Bruce K.& Teng, Nelson N. H.. Leukemia Inhibitory Factor Downregulates Human Papillomavirus-16 Oncogene Expression and Inhibits the Proliferation of Cervical Carcinoma Cells. Infectious Diseases in Obstetrics and Gynecology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-473536
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473536