Adenylyl Cyclase Signaling in the Developing Chick Heart : The Deranging Effect of Antiarrhythmic Drugs
Joint Authors
Kockova, Radka
Svatunkova, Jarmila
Hejnova, Lucie
Novotny, Jiri
Hahnova, Klara
Sedmera, David
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The adenylyl cyclase (AC) signaling system plays a crucial role in the regulation of cardiac contractility.
Here we analyzed the key components of myocardial AC signaling in the developing chick embryo and assessed the impact of selected β-blocking agents on this system.
Application of metoprolol and carvedilol, two commonly used β-blockers, at embryonic day (ED) 8 significantly downregulated (by about 40%) expression levels of AC5, the dominant cardiac AC isoform, and the amount of Gsα protein at ED9.
Activity of AC stimulated by forskolin was also significantly reduced under these conditions.
Interestingly, when administered at ED4, these drugs did not produce such profound changes in the myocardial AC signaling system, except for markedly increased expression of Giα protein.
These data indicate that β-blocking agents can strongly derange AC signaling during the first half of embryonic heart development.
American Psychological Association (APA)
Hejnova, Lucie& Hahnova, Klara& Kockova, Radka& Svatunkova, Jarmila& Sedmera, David& Novotny, Jiri. 2014. Adenylyl Cyclase Signaling in the Developing Chick Heart : The Deranging Effect of Antiarrhythmic Drugs. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-473543
Modern Language Association (MLA)
Hejnova, Lucie…[et al.]. Adenylyl Cyclase Signaling in the Developing Chick Heart : The Deranging Effect of Antiarrhythmic Drugs. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-473543
American Medical Association (AMA)
Hejnova, Lucie& Hahnova, Klara& Kockova, Radka& Svatunkova, Jarmila& Sedmera, David& Novotny, Jiri. Adenylyl Cyclase Signaling in the Developing Chick Heart : The Deranging Effect of Antiarrhythmic Drugs. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-473543
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473543