Molecular Nevogenesis
Joint Authors
Sanchez, Margaret I.
Grichnik, James M.
Ross, Andrew L.
Source
Dermatology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Despite recent advances, the biology underlying nevogenesis remains unclear.
Activating mutations in NRAS, HRAS, BRAF, and GNAQ have been identified in benign nevi.
Their presence roughly correlates with congenital, Spitz, acquired, and blue nevi, respectively.
These mutations are likely to play a critical role in driving nevogenesis.
While each mutation is able to activate the MAP kinase pathway, they also interact with a host of different proteins in other pathways.
The different melanocytic developmental pathways activated by each mutation cause the cells to migrate, proliferate, and differentiate to different extents within the skin.
This causes each mutation to give rise to a characteristic growth pattern.
The exact location and differentiation state of the cell of origin for benign moles remains to be discovered.
Further research is necessary to fully understand nevus development given that most of the same developmental pathways are also present in melanoma.
American Psychological Association (APA)
Ross, Andrew L.& Sanchez, Margaret I.& Grichnik, James M.. 2011. Molecular Nevogenesis. Dermatology Research and Practice،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-473549
Modern Language Association (MLA)
Ross, Andrew L.…[et al.]. Molecular Nevogenesis. Dermatology Research and Practice No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-473549
American Medical Association (AMA)
Ross, Andrew L.& Sanchez, Margaret I.& Grichnik, James M.. Molecular Nevogenesis. Dermatology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-473549
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473549