A Facile Synthesis of Pyrido[2′,3′ : 3,4]pyrazolo[1,5-a]pyrimidine and Pyrido[2′,3′:3,4]pyrazolo[5,1-c][1,2,4]triazine Bearing a Thiophene Moiety
Joint Authors
Ghabbour, Hazem A.
Dawood, Kamal M.
Attia, Mohamed I.
Fares, Mohamed
Elsaman, Tilal
Abdel-Aziz, Hatem A.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Pyridinone derivative 8 was synthesized and transformed into the respective chloropyridine 9, which was allowed to react with hydrazine hydrate to afford pyrazolo[3,4-b]pyridin-3-amine derivative 11.
Compound 11 was used as a key intermediate for a facile synthesis of the title compounds 14, 15, 17, 21a,b, and 24a–c where the reaction of 11 with some 1,3-dielecrophiles resulted in the formation of pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidines 14, 15, and 17, whereas diazotization of compound 11 gave the respective diazonium salt 18 which was coupled with some active methylene-containing compounds to give the corresponding hydrazones 19a,b and 22a–c.
Cyclization of the latter hydrazones yielded the pyrido[2′,3′:3,4]pyrazolo[5,1-c][1,2,4]triazines 21a,b and 24a–c, respectively.
American Psychological Association (APA)
Elsaman, Tilal& Fares, Mohamed& Abdel-Aziz, Hatem A.& Attia, Mohamed I.& Ghabbour, Hazem A.& Dawood, Kamal M.. 2013. A Facile Synthesis of Pyrido[2′,3′ : 3,4]pyrazolo[1,5-a]pyrimidine and Pyrido[2′,3′:3,4]pyrazolo[5,1-c][1,2,4]triazine Bearing a Thiophene Moiety. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-473566
Modern Language Association (MLA)
Elsaman, Tilal…[et al.]. A Facile Synthesis of Pyrido[2′,3′ : 3,4]pyrazolo[1,5-a]pyrimidine and Pyrido[2′,3′:3,4]pyrazolo[5,1-c][1,2,4]triazine Bearing a Thiophene Moiety. Journal of Chemistry No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-473566
American Medical Association (AMA)
Elsaman, Tilal& Fares, Mohamed& Abdel-Aziz, Hatem A.& Attia, Mohamed I.& Ghabbour, Hazem A.& Dawood, Kamal M.. A Facile Synthesis of Pyrido[2′,3′ : 3,4]pyrazolo[1,5-a]pyrimidine and Pyrido[2′,3′:3,4]pyrazolo[5,1-c][1,2,4]triazine Bearing a Thiophene Moiety. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-473566
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473566