Analysis of Safety from a Human Clinical Trial with Pterostilbene
Joint Authors
Griswold, Michael E.
Deschamp, David
Riche, Daniel M.
Sherman, Justin J.
McEwen, Corey L.
Wofford, Marion R.
Riche, Krista D.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-04
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Objectives.
The purpose of this trial was to evaluate the safety of long-term pterostilbene administration in humans.
Methodology.
The trial was a prospective, randomized, double-blind placebo-controlled intervention trial enrolling patients with hypercholesterolemia (defined as a baseline total cholesterol ≥200 mg/dL and/or baseline low-density lipoprotein cholesterol ≥100 mg/dL).
Eighty subjects were divided equally into one of four groups: (1) pterostilbene 125 mg twice daily, (2) pterostilbene 50 mg twice daily, (3) pterostilbene 50 mg + grape extract (GE) 100 mg twice daily, and (4) matching placebo twice daily for 6–8 weeks.
Safety markers included biochemical and subjective measures.
Linear mixed models were used to estimate primary safety measure treatment effects.
Results.
The majority of patients completed the trial (91.3%).
The average age was 54 years.
The majority of patients were females (71%) and Caucasians (70%).
There were no adverse drug reactions (ADRs) on hepatic, renal, or glucose markers based on biochemical analysis.
There were no statistically significant self-reported or major ADRs.
Conclusion.
Pterostilbene is generally safe for use in humans up to 250 mg/day.
American Psychological Association (APA)
Riche, Daniel M.& McEwen, Corey L.& Riche, Krista D.& Sherman, Justin J.& Wofford, Marion R.& Deschamp, David…[et al.]. 2013. Analysis of Safety from a Human Clinical Trial with Pterostilbene. Journal of Toxicology،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-473575
Modern Language Association (MLA)
Riche, Daniel M.…[et al.]. Analysis of Safety from a Human Clinical Trial with Pterostilbene. Journal of Toxicology No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-473575
American Medical Association (AMA)
Riche, Daniel M.& McEwen, Corey L.& Riche, Krista D.& Sherman, Justin J.& Wofford, Marion R.& Deschamp, David…[et al.]. Analysis of Safety from a Human Clinical Trial with Pterostilbene. Journal of Toxicology. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-473575
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473575