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Antiretroviral Therapy for HIV-2 Infection : Recommendations for Management in Low-Resource Settings
Joint Authors
Peterson, Kevin
Jallow, Sabelle
Rowland-Jones, Sarah L.
de Silva, Thushan I.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
HIV-2 contributes approximately a third to the prevalence of HIV in West Africa and is present in significant amounts in several low-income countries outside of West Africa with historical ties to Portugal.
It complicates HIV diagnosis, requiring more expensive and technically demanding testing algorithms.
Natural polymorphisms and patterns in the development of resistance to antiretrovirals are reviewed, along with their implications for antiretroviral therapy.
Nonnucleoside reverse transcriptase inhibitors, crucial in standard first-line regimens for HIV-1 in many low-income settings, have no effect on HIV-2.
Nucleoside analogues alone are not sufficiently potent enough to achieve durable virologic control.
Some protease inhibitors, in particular those without ritonavir boosting, are not sufficiently effective against HIV-2.
Following review of the available evidence and taking the structure and challenges of antiretroviral care in West Africa into consideration, the authors make recommendations and highlight the needs of special populations.
American Psychological Association (APA)
Peterson, Kevin& Jallow, Sabelle& Rowland-Jones, Sarah L.& de Silva, Thushan I.. 2011. Antiretroviral Therapy for HIV-2 Infection : Recommendations for Management in Low-Resource Settings. AIDS Research and Treatment،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-473592
Modern Language Association (MLA)
Peterson, Kevin…[et al.]. Antiretroviral Therapy for HIV-2 Infection : Recommendations for Management in Low-Resource Settings. AIDS Research and Treatment No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-473592
American Medical Association (AMA)
Peterson, Kevin& Jallow, Sabelle& Rowland-Jones, Sarah L.& de Silva, Thushan I.. Antiretroviral Therapy for HIV-2 Infection : Recommendations for Management in Low-Resource Settings. AIDS Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-473592
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473592