Age-Related Neurodegeneration and Memory Loss in Down Syndrome

Joint Authors

Lockrow, Jason P.
Fortress, Ashley M.
Granholm, Ann-Charlotte E.

Source

Current Gerontology and Geriatrics Research

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-03-20

Country of Publication

Egypt

No. of Pages

13

Main Subjects

Diseases

Abstract EN

Down syndrome (DS) is a condition where a complete or segmental chromosome 21 trisomy causes variable intellectual disability, and progressive memory loss and neurodegeneration with age.

Many research groups have examined development of the brain in DS individuals, but studies on age-related changes should also be considered, with the increased lifespan observed in DS.

DS leads to pathological hallmarks of Alzheimer's disease (AD) by 40 or 50 years of age.

Progressive age-related memory deficits occurring in both AD and in DS have been connected to degeneration of several neuronal populations, but mechanisms are not fully elucidated.

Inflammation and oxidative stress are early events in DS pathology, and focusing on these pathways may lead to development of successful intervention strategies for AD associated with DS.

Here we discuss recent findings and potential treatment avenues regarding development of AD neuropathology and memory loss in DS.

American Psychological Association (APA)

Lockrow, Jason P.& Fortress, Ashley M.& Granholm, Ann-Charlotte E.. 2012. Age-Related Neurodegeneration and Memory Loss in Down Syndrome. Current Gerontology and Geriatrics Research،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-473615

Modern Language Association (MLA)

Lockrow, Jason P.…[et al.]. Age-Related Neurodegeneration and Memory Loss in Down Syndrome. Current Gerontology and Geriatrics Research No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-473615

American Medical Association (AMA)

Lockrow, Jason P.& Fortress, Ashley M.& Granholm, Ann-Charlotte E.. Age-Related Neurodegeneration and Memory Loss in Down Syndrome. Current Gerontology and Geriatrics Research. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-473615

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-473615