Lactose Malabsorption Testing in Daily Clinical Practice : A Critical Retrospective Analysis and Comparison of the HydrogenMethane Breath Test and Genetic Test (CT-13910 Polymorphism) Results
Joint Authors
Stolba, Robert
Rezanka, Erwin
Enko, Dietmar
Halwachs-Baumann, Gabriele
Source
Gastroenterology Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The aim of this study was to establish a retrospective evaluation and comparison of the hydrogen/methane (H2/CH4) breath test and genetic test (C/T−13910 polymorphism) results in lactose malabsorption testing.
In total 263 consecutive patients with suspected lactose malabsorption were included in this study.
They underwent the H2/CH4 breath test following the ingestion of 50 g lactose and were tested for the C/T−13910 polymorphism.
In total 51 patients (19.4%) had a C/C−13910 genotype, indicating primary lactose malabsorption.
Only 19 patients (7.2%) also had a positive H2/CH4 breath test.
All in all 136 patients (51.69%) had a C/T−13910 and 76 patients (28.91%) a T/T−13910 genotype, indicating lactase persistence.
Four patients (1.5%) with the C/T−13910 genotype and one patient (0.4%) with the T/T−13910 genotype had a positive H2/CH4 breath test result, indicating secondary lactose malabsorption.
Cohen's Kappa measuring agreement between the two methods was 0.44.
Twenty patients (7.6%) with a positive H2/CH4 peak within 60 minutes after lactose ingestion were classified as patients with lactose-dependent small intestinal bacterial overgrowth (SIBO).
In conclusion, only moderate agreement between the breath test and the genetic test was shown.
Secondary lactose malabsorption as well as preanalytical limitations of the combined H2/CH4 breath test procedure can cause discrepant results.
This trial is registered with K-42-13.
American Psychological Association (APA)
Enko, Dietmar& Rezanka, Erwin& Stolba, Robert& Halwachs-Baumann, Gabriele. 2014. Lactose Malabsorption Testing in Daily Clinical Practice : A Critical Retrospective Analysis and Comparison of the HydrogenMethane Breath Test and Genetic Test (CT-13910 Polymorphism) Results. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-473646
Modern Language Association (MLA)
Enko, Dietmar…[et al.]. Lactose Malabsorption Testing in Daily Clinical Practice : A Critical Retrospective Analysis and Comparison of the HydrogenMethane Breath Test and Genetic Test (CT-13910 Polymorphism) Results. Gastroenterology Research and Practice No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-473646
American Medical Association (AMA)
Enko, Dietmar& Rezanka, Erwin& Stolba, Robert& Halwachs-Baumann, Gabriele. Lactose Malabsorption Testing in Daily Clinical Practice : A Critical Retrospective Analysis and Comparison of the HydrogenMethane Breath Test and Genetic Test (CT-13910 Polymorphism) Results. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-473646
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473646