One Function—Multiple Mechanisms : The Manifold Activities of p53 as a Transcriptional Repressor
Joint Authors
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-08
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Maintenance of genome integrity is a dynamic process involving complex regulation systems.
Defects in one or more of these pathways could result in cancer.
The most important tumor-suppressor is the transcription factor p53, and its functional inactivation is frequently observed in many tumor types.
The tumor suppressive function of p53 is mainly attributed to its ability to regulate numerous target genes at the transcriptional level.
While the mechanism of transcriptional induction by p53 is well characterized, p53-dependent repression is not understood in detail.
Here, we review the manifold mechanisms of p53 as a transcriptional repressor.
We classify two different categories of repressed genes based on the underlying mechanism, and novel mechanisms which involve regulation through noncoding RNAs are discussed.
The complete elucidation of p53 functions is important for our understanding of its tumor-suppressor activity and, therefore, represents the key for the development of novel therapeutic approaches.
American Psychological Association (APA)
Böhlig, Levin& Rother, Karen. 2011. One Function—Multiple Mechanisms : The Manifold Activities of p53 as a Transcriptional Repressor. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-473689
Modern Language Association (MLA)
Böhlig, Levin& Rother, Karen. One Function—Multiple Mechanisms : The Manifold Activities of p53 as a Transcriptional Repressor. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-473689
American Medical Association (AMA)
Böhlig, Levin& Rother, Karen. One Function—Multiple Mechanisms : The Manifold Activities of p53 as a Transcriptional Repressor. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-473689
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473689