Fatal CMV-Infection after Autologous Stem Cell Transplantation in Refractory Systemic Lupus Erythematosus
Joint Authors
Zeher, Margit
Váróczy, László
Szegedi, Gyula
Illés, Árpád
Tarr, Tünde
Kiss, Emese
Source
Case Reports in Transplantation
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-29
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
High-dose chemotherapy followed by autologous stem cell transplantation can be a rescue for patients with severe refractory systemic lupus erythematosus (SLE).
However, the procedure might have fatal complications including infections and bleeding.
We report on a young female patient with SLE whose disease started in her early childhood.
After many years, severe renal, neurological, and bone marrow involvement developed that did not respond to conventional therapy.
She was selected for autologous stem cell transplantation.
A successful peripheral stem cell apheresis was performed in March 2006.
The nonselected graft was reinfused in August 2006 after a conditioning chemotherapy containing high-dose cyclophosphamide and antithymocyte globulin.
Engraftment was detected within 11 days.
On the 38th posttransplant day, severe cytomegalovirus (CMV) infection developed that included pneumonitis, hepatitis, and pancytopenia.
The patient died in a week due to multiorgan failure.
With her case, we want to call the attention to this rare, but lethal complication of the autologous transplantation.
American Psychological Association (APA)
Váróczy, László& Kiss, Emese& Tarr, Tünde& Zeher, Margit& Szegedi, Gyula& Illés, Árpád. 2012. Fatal CMV-Infection after Autologous Stem Cell Transplantation in Refractory Systemic Lupus Erythematosus. Case Reports in Transplantation،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-473701
Modern Language Association (MLA)
Váróczy, László…[et al.]. Fatal CMV-Infection after Autologous Stem Cell Transplantation in Refractory Systemic Lupus Erythematosus. Case Reports in Transplantation No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-473701
American Medical Association (AMA)
Váróczy, László& Kiss, Emese& Tarr, Tünde& Zeher, Margit& Szegedi, Gyula& Illés, Árpád. Fatal CMV-Infection after Autologous Stem Cell Transplantation in Refractory Systemic Lupus Erythematosus. Case Reports in Transplantation. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-473701
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473701