Hypertonic Saline in Treatment of Pulmonary Disease in Cystic Fibrosis
Joint Authors
McElvaney, Noel G.
Reeves, Emer P.
Pohl, Kerstin
Molloy, Kevin
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
The pathogenesis of lung disease in cystic fibrosis is characterised by decreased airway surface liquid volume and subsequent failure of normal mucociliary clearance.
Mucus within the cystic fibrosis airways is enriched in negatively charged matrices composed of DNA released from colonizing bacteria or inflammatory cells, as well as F-actin and elevated concentrations of anionic glycosaminoglycans.
Therapies acting against airway mucus in cystic fibrosis include aerosolized hypertonic saline.
It has been shown that hypertonic saline possesses mucolytic properties and aids mucociliary clearance by restoring the liquid layer lining the airways.
However, recent clinical and bench-top studies are beginning to broaden our view on the beneficial effects of hypertonic saline, which now extend to include anti-infective as well as anti-inflammatory properties.
This review aims to discuss the described therapeutic benefits of hypertonic saline and specifically to identify novel models of hypertonic saline action independent of airway hydration.
American Psychological Association (APA)
Reeves, Emer P.& Molloy, Kevin& Pohl, Kerstin& McElvaney, Noel G.. 2012. Hypertonic Saline in Treatment of Pulmonary Disease in Cystic Fibrosis. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-473717
Modern Language Association (MLA)
Reeves, Emer P.…[et al.]. Hypertonic Saline in Treatment of Pulmonary Disease in Cystic Fibrosis. The Scientific World Journal No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-473717
American Medical Association (AMA)
Reeves, Emer P.& Molloy, Kevin& Pohl, Kerstin& McElvaney, Noel G.. Hypertonic Saline in Treatment of Pulmonary Disease in Cystic Fibrosis. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-473717
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473717