Cancer Stem Cells : Repair Gone Awry?
Joint Authors
Omenetti, Alessia
Diehl, Anna Mae
Rangwala, Fatima
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Because cell turnover occurs in all adult organs, stem/progenitor cells within the stem-cell niche of each tissue must be appropriately mobilized and differentiated to maintain normal organ structure and function.
Tissue injury increases the demands on this process, and thus may unmask defective regulation of pathways, such as Hedgehog (Hh), that modulate progenitor cell fate.
Hh pathway dysregulation has been demonstrated in many types of cancer, including pancreatic and liver cancers, in which defective Hh signaling has been linked to outgrowth of Hh-responsive cancer stem-initiating cells and stromal elements.
Hence, the Hh pathway might be a therapeutic target in such tumors.
American Psychological Association (APA)
Rangwala, Fatima& Omenetti, Alessia& Diehl, Anna Mae. 2010. Cancer Stem Cells : Repair Gone Awry?. Journal of Oncology،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-473727
Modern Language Association (MLA)
Rangwala, Fatima…[et al.]. Cancer Stem Cells : Repair Gone Awry?. Journal of Oncology No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-473727
American Medical Association (AMA)
Rangwala, Fatima& Omenetti, Alessia& Diehl, Anna Mae. Cancer Stem Cells : Repair Gone Awry?. Journal of Oncology. 2010. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-473727
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473727