Biomarkers of Oxidative Stress and Personalized Treatment of Pulmonary Tuberculosis : Emerging Role of Gamma-Glutamyltransferase
Joint Authors
Longo-Mbenza, Benjamin
Parra, Henri-Joseph
Mokondjimobe, Etienne
Akiana, Jean
Ndalla, Ulrich Oswald
Dossou-Yovo, Regis
Mboussa, Joseph
Source
Advances in Pharmacological Sciences
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The objectives were (i) to evaluate the impact of acute pulmonary tuberculosis (PTB) and anti-TB therapy on the relationship between AST, ALT, and GGT levels in absence of conditions related to hepatotoxicity; (ii) to evaluate the rate and the time of alterations of AST, ALT, and GGT.
Design and Methods.
A prospective followup of 40 adults (21 males; mean age of 34.7±5.8 years) with active PTB on initial phase and continuation phase anti-TB.
Results.
Only 3% (n=1) developed a transient and benign ADR at day 30 without interruption of anti-TB treatment.
Within normal ranges, GGT decreased significantly from day 0 to day 60, while AST and ALT increased significantly and respectively.
During day 0–day 60, there was a significant, negative, and independent association between GGT and AST.
Conclusion.
The initial two months led to significant improvement of oxidative stress.
Values of oxidative markers in normal ranges might predict low rate of ADR.
American Psychological Association (APA)
Mokondjimobe, Etienne& Longo-Mbenza, Benjamin& Akiana, Jean& Ndalla, Ulrich Oswald& Dossou-Yovo, Regis& Mboussa, Joseph…[et al.]. 2012. Biomarkers of Oxidative Stress and Personalized Treatment of Pulmonary Tuberculosis : Emerging Role of Gamma-Glutamyltransferase. Advances in Pharmacological Sciences،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-473745
Modern Language Association (MLA)
Mokondjimobe, Etienne…[et al.]. Biomarkers of Oxidative Stress and Personalized Treatment of Pulmonary Tuberculosis : Emerging Role of Gamma-Glutamyltransferase. Advances in Pharmacological Sciences No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-473745
American Medical Association (AMA)
Mokondjimobe, Etienne& Longo-Mbenza, Benjamin& Akiana, Jean& Ndalla, Ulrich Oswald& Dossou-Yovo, Regis& Mboussa, Joseph…[et al.]. Biomarkers of Oxidative Stress and Personalized Treatment of Pulmonary Tuberculosis : Emerging Role of Gamma-Glutamyltransferase. Advances in Pharmacological Sciences. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-473745
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473745