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The Peroxisome Proliferator-Activated Receptor Gamma System Regulates Ultraviolet B-Induced Prostaglandin E2 Production in Human Epidermal Keratinocytes
Joint Authors
Travers, Jeffrey B.
Martel, Kellie Clay
Zhang, Qiwei
Jernigan, Danielle
Konger, Raymond L.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Studies using PPARγ agonists in mouse skin have suggested that peroxisome proliferator-activated receptor gamma (PPARγ) is irrelevant to cutaneous photobiology.
However, in several epithelial cell lines, ultraviolet B (UVB) has been shown to induce the nonenzymatic production of oxidized phospholipids that act as PPARγ agonists.
UVB is also a potent inducer of prostaglandin E2 (PGE2) production and COX-2 expression in keratinocytes and PPARγ is coupled to increased PGE2 production in other cell lines.
In this current study, we demonstrate that PPARγ agonists, but not PPARα or PPARβ/δ agonists, induce PGE2 production and COX-2 expression in primary human keratinocytes (PHKs).
Importantly, PPARγ agonist-induced COX-2 expression and PGE2 production were partially inhibited by the PPARγ antagonist, GW9662, indicating that both PPARγ-dependent and -independent pathways are likely involved.
GW9662 also suppressed UVB and tert-butylhydroperoxide- (TBH-) induced PGE2 production in PHKs and intact human epidermis and partially inhibited UVB-induced COX-2 expression in PHKs.
These findings provide evidence that PPARγ is relevant to cutaneous photobiology in human epidermis.
American Psychological Association (APA)
Konger, Raymond L.& Martel, Kellie Clay& Jernigan, Danielle& Zhang, Qiwei& Travers, Jeffrey B.. 2010. The Peroxisome Proliferator-Activated Receptor Gamma System Regulates Ultraviolet B-Induced Prostaglandin E2 Production in Human Epidermal Keratinocytes. PPAR Research،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-473780
Modern Language Association (MLA)
Konger, Raymond L.…[et al.]. The Peroxisome Proliferator-Activated Receptor Gamma System Regulates Ultraviolet B-Induced Prostaglandin E2 Production in Human Epidermal Keratinocytes. PPAR Research No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-473780
American Medical Association (AMA)
Konger, Raymond L.& Martel, Kellie Clay& Jernigan, Danielle& Zhang, Qiwei& Travers, Jeffrey B.. The Peroxisome Proliferator-Activated Receptor Gamma System Regulates Ultraviolet B-Induced Prostaglandin E2 Production in Human Epidermal Keratinocytes. PPAR Research. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-473780
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473780