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The Role of the Endothelium in HPS Pathogenesis and Potential Therapeutic Approaches
Joint Authors
Gavrilovskaya, Irina
Dalrymple, Nadine A.
Mackow, Erich R.
Gorbunova, Elena
Matthys, Valery
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
American hantaviruses cause a highly lethal acute pulmonary edema termed hantavirus pulmonary syndrome (HPS).
Hantaviruses nonlytically infect endothelial cells and cause dramatic changes in barrier functions of the endothelium without disrupting the endothelium.
Instead hantaviruses cause changes in the function of infected endothelial cells that normally regulate fluid barrier functions of capillaries.
The endothelium of arteries, veins, and lymphatic vessels is unique and central to the function of vast pulmonary capillary beds, which regulate pulmonary fluid accumulation.
The endothelium maintains vascular barrier functions through a complex series of redundant receptors and signaling pathways that serve to both permit fluid and immune cell efflux into tissues and restrict tissue edema.
Infection of the endothelium provides several mechanisms for hantaviruses to alter capillary permeability but also defines potential therapeutic targets for regulating acute pulmonary edema and HPS disease.
Here we discuss interactions of HPS causing hantaviruses with the endothelium, potential endothelial cell-directed permeability mechanisms, and therapeutic targeting of the endothelium as a means of reducing the severity of HPS disease.
American Psychological Association (APA)
Gavrilovskaya, Irina& Gorbunova, Elena& Matthys, Valery& Dalrymple, Nadine A.& Mackow, Erich R.. 2012. The Role of the Endothelium in HPS Pathogenesis and Potential Therapeutic Approaches. Advances in Virology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-473782
Modern Language Association (MLA)
Gavrilovskaya, Irina…[et al.]. The Role of the Endothelium in HPS Pathogenesis and Potential Therapeutic Approaches. Advances in Virology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-473782
American Medical Association (AMA)
Gavrilovskaya, Irina& Gorbunova, Elena& Matthys, Valery& Dalrymple, Nadine A.& Mackow, Erich R.. The Role of the Endothelium in HPS Pathogenesis and Potential Therapeutic Approaches. Advances in Virology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-473782
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473782