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Research Strategies in the Study of the Pro-Oxidant Nature of Polyphenol Nutraceuticals
Joint Authors
Schuck, Alyssa G.
Babich, Harvey
Weisburg, Jeffrey H.
Zuckerbraun, Harriet L.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Polyphenols of phytochemicals are thought to exhibit chemopreventive effects against cancer.
These plant-derived antioxidant polyphenols have a dual nature, also acting as pro-oxidants, generating reactive oxygen species (ROS), and causing oxidative stress.
When studying the overall cytotoxicity of polyphenols, research strategies need to distinguish the cytotoxic component derived from the polyphenol per se from that derived from the generated ROS.
Such strategies include (a) identifying hallmarks of oxidative damage, such as depletion of intracellular glutathione and lipid peroxidation, (b) classical manipulations, such as polyphenol exposures in the absence and presence of antioxidant enzymes (i.e., catalase and superoxide dismutase) and of antioxidants (e.g., glutathione and N-acetylcysteine) and cotreatments with glutathione depleters, and (c) more recent manipulations, such as divalent cobalt and pyruvate to scavenge ROS.
Attention also must be directed to the influence of iron and copper ions and to the level of polyphenols, which mediate oxidative stress.
American Psychological Association (APA)
Babich, Harvey& Schuck, Alyssa G.& Weisburg, Jeffrey H.& Zuckerbraun, Harriet L.. 2011. Research Strategies in the Study of the Pro-Oxidant Nature of Polyphenol Nutraceuticals. Journal of Toxicology،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-473807
Modern Language Association (MLA)
Babich, Harvey…[et al.]. Research Strategies in the Study of the Pro-Oxidant Nature of Polyphenol Nutraceuticals. Journal of Toxicology No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-473807
American Medical Association (AMA)
Babich, Harvey& Schuck, Alyssa G.& Weisburg, Jeffrey H.& Zuckerbraun, Harriet L.. Research Strategies in the Study of the Pro-Oxidant Nature of Polyphenol Nutraceuticals. Journal of Toxicology. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-473807
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473807