N-3 (Omega-3) Fatty Acids in Postpartum Depression : Implications for Prevention and Treatment
Author
Source
Depression Research and Treatment
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-27
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
A growing body of clinical and epidemiological evidence suggests that low dietary intake and/or tissue levels of n-3 (omega-3) polyunsaturated fatty acids (PUFAs) are associated with postpartum depression.
Low tissue levels of n-3 PUFAs, particularly docosahexaenoic acid (DHA), are reported in patients with either postpartum or nonpuerperal depression.
Moreover, the physiological demands of pregnancy and lactation put childbearing women at particular risk of experiencing a loss of DHA from tissues including the brain, especially in individuals with inadequate dietary n-3 PUFA intake or suboptimal metabolic capabilities.
Animal studies indicate that decreased brain DHA in postpartum females leads to several depression-associated neurobiological changes including decreased hippocampal brain-derived neurotrophic factor and augmented hypothalamic-pituitary-adrenal responses to stress.
Taken together, these findings support a role for decreased brain n-3 PUFAs in the multifactorial etiology of depression, particularly postpartum depression.
These findings, and their implications for research and clinical practice, are discussed.
American Psychological Association (APA)
Levant, Beth. 2010. N-3 (Omega-3) Fatty Acids in Postpartum Depression : Implications for Prevention and Treatment. Depression Research and Treatment،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-473811
Modern Language Association (MLA)
Levant, Beth. N-3 (Omega-3) Fatty Acids in Postpartum Depression : Implications for Prevention and Treatment. Depression Research and Treatment No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-473811
American Medical Association (AMA)
Levant, Beth. N-3 (Omega-3) Fatty Acids in Postpartum Depression : Implications for Prevention and Treatment. Depression Research and Treatment. 2010. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-473811
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473811