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Punicalagin and Ellagic Acid Demonstrate Antimutagenic Activity and Inhibition of Benzo[a]pyrene Induced DNA Adducts
Joint Authors
Zahin, Maryam
Gupta, Ramesh C.
Aqil, Farrukh
Ahmad, Iqbal
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Punicalagin (PC) is an ellagitannin found in the fruit peel of Punica granatum.
We have demonstrated antioxidant and antigenotoxic properties of Punica granatum and showed that PC and ellagic acid (EA) are its major constituents.
In this study, we demonstrate the antimutagenic potential, inhibition of BP-induced DNA damage, and antiproliferative activity of PC and EA.
Incubation of BP with rat liver microsomes, appropriate cofactors, and DNA in the presence of vehicle or PC and EA showed significant inhibition of the resultant DNA adducts, with essentially complete inhibition (97%) at 40 μM by PC and 77% inhibition by EA.
Antimutagenicity was tested by Ames test.
PC and EA dose-dependently and markedly antagonized the effect of tested mutagens, sodium azide, methyl methanesulfonate, benzo[a]pyrene, and 2-aminoflourine, with maximum inhibition of mutagenicity up to 90 percent.
Almost all the doses tested (50–500 μM) exhibited significant antimutagenicity.
A profound antiproliferative effect on human lung cancer cells was also shown with PC and EA.
Together, our data show that PC and EA are pomegranate bioactives responsible for inhibition of BP-induced DNA adducts and strong antimutagenic, antiproliferative activities.
However, these compounds are to be evaluated in suitable animal model to assess their therapeutic efficacy against cancer.
American Psychological Association (APA)
Zahin, Maryam& Ahmad, Iqbal& Gupta, Ramesh C.& Aqil, Farrukh. 2014. Punicalagin and Ellagic Acid Demonstrate Antimutagenic Activity and Inhibition of Benzo[a]pyrene Induced DNA Adducts. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-473821
Modern Language Association (MLA)
Zahin, Maryam…[et al.]. Punicalagin and Ellagic Acid Demonstrate Antimutagenic Activity and Inhibition of Benzo[a]pyrene Induced DNA Adducts. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-473821
American Medical Association (AMA)
Zahin, Maryam& Ahmad, Iqbal& Gupta, Ramesh C.& Aqil, Farrukh. Punicalagin and Ellagic Acid Demonstrate Antimutagenic Activity and Inhibition of Benzo[a]pyrene Induced DNA Adducts. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-473821
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473821