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Evaluating the Immunogenicity of Protein Drugs by Applying In Vitro MHC Binding Data and the Immune Epitope Database and Analysis Resource
Joint Authors
Weiskopf, Daniela
Kolla, Ravi V.
Sette, Alessandro
Fleri, Ward
Sidney, John
Peters, Bjoern
Paul, Sinu
Kim, Yohan
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The immune system has evolved to become highly specialized in recognizing and responding to pathogens and foreign molecules.
Specifically, the function of HLA class II is to ensure that a sufficient sample of peptides derived from foreign molecules is presented to T cells.
This leads to an important concern in human drug development as the possible immunogenicity of biopharmaceuticals, especially those intended for chronic administration, can lead to reduced efficacy and an undesired safety profile for biological therapeutics.
As part of this review, we will highlight the molecular basis of antigen presentation as a key step in the induction of T cell responses, emphasizing the events associated with peptide binding to polymorphic and polygenic HLA class II molecules.
We will further review methodologies that predict HLA class II binding peptides and candidate epitopes.
We will focus on tools provided by the Immune Epitope Database and Analysis Resource, discussing the basic features of different prediction methods, the objective evaluation of prediction quality, and general guidelines for practical use of these tools.
Finally the use, advantages, and limitations of the methodology will be demonstrated in a review of two previous studies investigating the immunogenicity of erythropoietin and timothy grass pollen.
American Psychological Association (APA)
Paul, Sinu& Kolla, Ravi V.& Sidney, John& Weiskopf, Daniela& Fleri, Ward& Kim, Yohan…[et al.]. 2013. Evaluating the Immunogenicity of Protein Drugs by Applying In Vitro MHC Binding Data and the Immune Epitope Database and Analysis Resource. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-473848
Modern Language Association (MLA)
Paul, Sinu…[et al.]. Evaluating the Immunogenicity of Protein Drugs by Applying In Vitro MHC Binding Data and the Immune Epitope Database and Analysis Resource. Clinical and Developmental Immunology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-473848
American Medical Association (AMA)
Paul, Sinu& Kolla, Ravi V.& Sidney, John& Weiskopf, Daniela& Fleri, Ward& Kim, Yohan…[et al.]. Evaluating the Immunogenicity of Protein Drugs by Applying In Vitro MHC Binding Data and the Immune Epitope Database and Analysis Resource. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-473848
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473848