Immunohistological Localization of BMP-2, BMP-7, and Their Receptors in Knee Joints with Focal Cartilage Lesions
Joint Authors
Lohrmann, Christian
Südkamp, Norbert P.
Mehlhorn, Alexander T.
Pilz, Ingo H.
Dovi-Akue, David
Niemeyer, Philipp
Schmal, Hagen
Kirchhoff, Christina
Gerlach, Ulrike
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Introduction.
Although it is well known that BMP-2 and BMP-7 play significant roles in cartilage metabolism, data about intra-articular expression and localization of these proteins and their receptors in humans are rare.
Methods.
Biopsies of synovia and debrided cartilage were taken in patients undergoing autologous chondrocyte implantation.
Expression of BMP-2, BMP-7, and their receptors BMPR-1A, BMPR-1B and BMPR-2 were semiquantitatively evaluated by immunohistological staining.
Results.
BMP-7 was equally highly expressed in all cartilage and synovial biopsies.
Increased levels of BMPR-1A, but not of BMPR-1B, and BMPR-2, were found in all synovial and 47% of all cartilage samples (P=0.002).
BMP-2 was positively scored in 47% of all cartilage and 40% of all synovial specimens.
Defect size, KOSS, Henderson or Kellgren-Lawrence score did not statistically significant correlate with the expression of the analyzed proteins or Mankin and Pritzker scores.
Duration of symptoms and localization of lesions were associated with KOSS (P<0.02), but there was no influence of these parameters on protein expression.
Conclusions.
BMP-2, BMP-7, and BMPR-1A were expressed in cartilage and synovia of knees with focal cartilage lesions.
Although defect localization and duration of symptoms decisively influence KOSS, there was no associated alteration of protein expression observed.
American Psychological Association (APA)
Schmal, Hagen& Mehlhorn, Alexander T.& Pilz, Ingo H.& Dovi-Akue, David& Kirchhoff, Christina& Südkamp, Norbert P.…[et al.]. 2012. Immunohistological Localization of BMP-2, BMP-7, and Their Receptors in Knee Joints with Focal Cartilage Lesions. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-473853
Modern Language Association (MLA)
Schmal, Hagen…[et al.]. Immunohistological Localization of BMP-2, BMP-7, and Their Receptors in Knee Joints with Focal Cartilage Lesions. The Scientific World Journal No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-473853
American Medical Association (AMA)
Schmal, Hagen& Mehlhorn, Alexander T.& Pilz, Ingo H.& Dovi-Akue, David& Kirchhoff, Christina& Südkamp, Norbert P.…[et al.]. Immunohistological Localization of BMP-2, BMP-7, and Their Receptors in Knee Joints with Focal Cartilage Lesions. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-473853
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473853