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Structure and Stability of a Dimeric G-Quadruplex Formed by Cyclic Oligonucleotides
Joint Authors
Viladoms, Júlia
Pedroso, Enrique
Casals, Joan
González, Carlos
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We have studied the structure and stability of the cyclic dodecamer d
In the presence of sodium, NMR data are consistent with a dimeric structure of the molecule in which two cycles self-associate forming a quadruplex with three guanine tetrads connected by edgewise loops.
The two macrocycles are arranged in a parallel way, and the dimeric structure exhibits a high melting temperature.
These results indicate that cyclization of the phosphodiester chain does not prevent quadruplex formation, although it affects the global topology of the quadruplex.
American Psychological Association (APA)
Casals, Joan& Viladoms, Júlia& Pedroso, Enrique& González, Carlos. 2010. Structure and Stability of a Dimeric G-Quadruplex Formed by Cyclic Oligonucleotides. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-473865
Modern Language Association (MLA)
Casals, Joan…[et al.]. Structure and Stability of a Dimeric G-Quadruplex Formed by Cyclic Oligonucleotides. Journal of Nucleic Acids No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-473865
American Medical Association (AMA)
Casals, Joan& Viladoms, Júlia& Pedroso, Enrique& González, Carlos. Structure and Stability of a Dimeric G-Quadruplex Formed by Cyclic Oligonucleotides. Journal of Nucleic Acids. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-473865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473865