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Activation of Mitogen-Activated Protein Kinase in Descending Pain Modulatory System
Joint Authors
Imbe, Hiroki
Kaneoke, Yoshiki
Kimura, Akihisa
Donishi, Tomohiro
Senba, Emiko
Yokoi, Isao
Source
Journal of Signal Transduction
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The descending pain modulatory system is thought to undergo plastic changes following peripheral tissue injury and exerts bidirectional (facilitatory and inhibitory) influence on spinal nociceptive transmission.
The mitogen-activated protein kinases (MAPKs) superfamily consists of four main members: the extracellular signal-regulated protein kinase1/2 (ERK1/2), the c-Jun N-terminal kinases (JNKs), the p38 MAPKs, and the ERK5.
MAPKs not only regulate cell proliferation and survival but also play important roles in synaptic plasticity and memory formation.
Recently, many studies have demonstrated that noxious stimuli activate MAPKs in several brain regions that are components of descending pain modulatory system.
They are involved in pain perception and pain-related emotional responses.
In addition, psychophysical stress also activates MAPKs in these brain structures.
Greater appreciation of the convergence of mechanisms between noxious stimuli- and psychological stress-induced neuroplasticity is likely to lead to the identification of novel targets for a variety of pain syndromes.
American Psychological Association (APA)
Imbe, Hiroki& Senba, Emiko& Kimura, Akihisa& Donishi, Tomohiro& Yokoi, Isao& Kaneoke, Yoshiki. 2010. Activation of Mitogen-Activated Protein Kinase in Descending Pain Modulatory System. Journal of Signal Transduction،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-473868
Modern Language Association (MLA)
Imbe, Hiroki…[et al.]. Activation of Mitogen-Activated Protein Kinase in Descending Pain Modulatory System. Journal of Signal Transduction No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-473868
American Medical Association (AMA)
Imbe, Hiroki& Senba, Emiko& Kimura, Akihisa& Donishi, Tomohiro& Yokoi, Isao& Kaneoke, Yoshiki. Activation of Mitogen-Activated Protein Kinase in Descending Pain Modulatory System. Journal of Signal Transduction. 2010. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-473868
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473868