Cytokines and HCV-Related Disorders
Joint Authors
Fallahi, Poupak
Antonelli, Alessandro
Ferri, Clodoveo
Sansonno, Domenico
Ferrari, Silvia Martina
Corrado, Alda
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cytokines are intercellular mediators involved in viral control and liver damage being induced by infection with hepatitis C virus (HCV).
The complex cytokine network operating during initial infection allows a coordinated, effective development of both innate and adaptive immune responses.
However, HCV interferes with cytokines at various levels and escapes immune response by inducing a T-helper (Th)2/T cytotoxic 2 cytokine profile.
Inability to control infection leads to the recruitment of inflammatory infiltrates into the liver parenchyma by interferon (IFN)-gamma-inducible CXC chemokine ligand (CXCL)-9, -10, and -11 chemokines, which results in sustained liver damage and eventually in liver cirrhosis.
The most important systemic HCV-related extrahepatic diseases—mixed cryoglobulinemia, lymphoproliferative disorders, thyroid autoimmune disorders, and type 2 diabetes—are associated with a complex dysregulation of the cytokine/chemokine network, involving proinflammatory and Th1 chemokines.
The therapeutical administration of cytokines such as IFN-alpha may result in viral clearance during persistent infection and reverts this process.
American Psychological Association (APA)
Fallahi, Poupak& Ferri, Clodoveo& Ferrari, Silvia Martina& Corrado, Alda& Sansonno, Domenico& Antonelli, Alessandro. 2012. Cytokines and HCV-Related Disorders. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-473873
Modern Language Association (MLA)
Fallahi, Poupak…[et al.]. Cytokines and HCV-Related Disorders. Clinical and Developmental Immunology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-473873
American Medical Association (AMA)
Fallahi, Poupak& Ferri, Clodoveo& Ferrari, Silvia Martina& Corrado, Alda& Sansonno, Domenico& Antonelli, Alessandro. Cytokines and HCV-Related Disorders. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-473873
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473873