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Gastrointestinal Complications in 147 Consecutive Patients with Peritoneal Surface Malignancy Treated by Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy
Joint Authors
Chang, David
Sugarbaker, Paul H.
Casado-Adam, Angela
Stuart, O. Anthony
Alderman, Robert
Source
International Journal of Surgical Oncology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is increasingly used in the treatment of peritoneal carcinomatosis from gastrointestinal malignancies.
The purpose of this study is to reevaluate the incidence of gastrointestinal events and identify risk factors associated with this treatment approach.
Between January 1, 2006 and December 31, 2009, 147 patients with appendiceal and colorectal carcinomatosis were treated.
Gastrointestinal events were analyzed.
The overall incidence of grade I–IV gastrointestinal events was 17%.
There were 4 grade III gastrointestinal events that occurred in 4 patients and 11 grade IV gastrointestinal events that occurred in 8 patients.
On univariate analysis of grade I–IV events a statistically significant association was observed with the following variables: histological grade, peritoneal cancer index (PCI), small bowel resection, colorectal anastomosis, and the number of anastomoses performed per patient.
By multivariate analysis, PCI was identified as the only independent risk factor for gastrointestinal complications.
CRS combined with a uniform HIPEC regimen is associated with a 17% gastrointestinal morbidity rate (grade I–IV).
The frequency of gastrointestinal complications was associated with a large extent of disease measured by PCI (>30).
American Psychological Association (APA)
Casado-Adam, Angela& Alderman, Robert& Stuart, O. Anthony& Chang, David& Sugarbaker, Paul H.. 2011. Gastrointestinal Complications in 147 Consecutive Patients with Peritoneal Surface Malignancy Treated by Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy. International Journal of Surgical Oncology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-473915
Modern Language Association (MLA)
Casado-Adam, Angela…[et al.]. Gastrointestinal Complications in 147 Consecutive Patients with Peritoneal Surface Malignancy Treated by Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy. International Journal of Surgical Oncology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-473915
American Medical Association (AMA)
Casado-Adam, Angela& Alderman, Robert& Stuart, O. Anthony& Chang, David& Sugarbaker, Paul H.. Gastrointestinal Complications in 147 Consecutive Patients with Peritoneal Surface Malignancy Treated by Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy. International Journal of Surgical Oncology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-473915
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473915