Rotigotine in the Long-Term Treatment of Severe RLS with Augmentation : A Series of 28 Cases
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This structured clinical observation includes 28 patients with severe RLS, severe augmentation, and previously frustrating changes of dopaminergic treatment.
All were switched from their current dopaminergic regimen to an individually adjusted rotigotine monotherapy; dosages were kept stable for 12 months.
Follow-up exams were performed after 1, 3, 6, and 12 months.
Severity of RLS symptoms (IRLS), augmentation (ASRS), depressive symptoms (BDI), and daytime sleepiness (ESS) were assessed at all visits.
Median rotigotine dose was 4 mg.
27 of the 28 patients showed a major to complete reduction of RLS symptoms.
IRLS and BDI scores (both P<.001), but not ESS scores, were significantly reduced.
IRLS and BDI amelioration remained stable over the 12-month follow-up period.
Augmentation occurred in only one patient.
71.4% suffered at least one mostly mild side effect; most common were increased appetite with compulsive eating (42.9%), application site reaction (28.6%), and nausea (14.3%).
In the clinical setting, rotigotine seems to be valuable for the long-term treatment of patients with severe RLS and augmentation.
American Psychological Association (APA)
Godau, Jana& Berg, Daniela. 2011. Rotigotine in the Long-Term Treatment of Severe RLS with Augmentation : A Series of 28 Cases. Sleep Disorders،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-473925
Modern Language Association (MLA)
Godau, Jana& Berg, Daniela. Rotigotine in the Long-Term Treatment of Severe RLS with Augmentation : A Series of 28 Cases. Sleep Disorders No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-473925
American Medical Association (AMA)
Godau, Jana& Berg, Daniela. Rotigotine in the Long-Term Treatment of Severe RLS with Augmentation : A Series of 28 Cases. Sleep Disorders. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-473925
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473925